Next Article in Journal
Biological and Pharmacological Activities of Squalene and Related Compounds: Potential Uses in Cosmetic Dermatology
Previous Article in Journal
Antimicrobial Activity of Some Thiourea Derivatives and Their Nickel and Copper Complexes
Molecules 2009, 14(1), 528-539; doi:10.3390/molecules14010528
Communication

“Flash” Solvent-free Synthesis of Triazoles Using a Supported Catalyst

1,2
,
2
,
1
 and
1,*
1 Laboratoire de Pharmacologie Chimique et Génétique UMR8151 CNRS - U640 INSERM – IFR2769, Ecole Nationale Supérieure de Chimie de Paris, 11, rue Pierre et Marie Curie, 75005 Paris, France 2 Laboratoire de Synthèse Organique et Application, Faculté des Sciences de Bizerte, Université du 7 Novembre à Carthage, 7021 Jarzouna Bizerte, Tunisia
* Author to whom correspondence should be addressed.
Received: 8 January 2009 / Revised: 20 January 2009 / Accepted: 22 January 2009 / Published: 22 January 2009
Download PDF [231 KB, uploaded 18 June 2014]

Abstract

A solvent-free synthesis of 1,4-disubstituted-1,2,3-triazoles using neat azides and alkynes and a copper(I) polymer supported catalyst (Amberlyst® A21•CuI) is presented herein. As it provides the products in high yields and purities within minutes, this method thus being characterized as a "flash" synthesis, and was exemplified through the synthesis of a 24-compound library on a small scale.
Keywords: Click chemistry; Huisgen’s cycloaddition; Copper (I) catalysis; Triazoles; Supported catalyst; Solvent-free Click chemistry; Huisgen’s cycloaddition; Copper (I) catalysis; Triazoles; Supported catalyst; Solvent-free
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote
MDPI and ACS Style

Jlalia, I.; Meganem, F.; Herscovici, J.; Girard, C. “Flash” Solvent-free Synthesis of Triazoles Using a Supported Catalyst. Molecules 2009, 14, 528-539.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

Cited By

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert