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• Jlalia, I
• Meganem, F
• Herscovici, J
• Girard, C
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• Jlalia, I
• Meganem, F
• Herscovici, J
• Girard, C
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• Jlalia, I
• Meganem, F
• Herscovici, J
• Girard, C

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Molecules 2009, 14(1), 528-539; doi:10.3390/molecules14010528

Communication

“Flash” Solvent-free Synthesis of Triazoles Using a Supported Catalyst

Ibtissem Jlalia ^1,2 , Faouzi Meganem ² , Jean Herscovici ¹  and Christian Girard ^1,*

¹ Laboratoire de Pharmacologie Chimique et Génétique UMR8151 CNRS - U640 INSERM – IFR2769, Ecole Nationale Supérieure de Chimie de Paris, 11, rue Pierre et Marie Curie, 75005 Paris, France ² Laboratoire de Synthèse Organique et Application, Faculté des Sciences de Bizerte, Université du 7 Novembre à Carthage, 7021 Jarzouna Bizerte, Tunisia

* Author to whom correspondence should be addressed.

Received: 8 January 2009; in revised form: 20 January 2009 / Accepted: 22 January 2009 / Published: 22 January 2009

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Abstract: A solvent-free synthesis of 1,4-disubstituted-1,2,3-triazoles using neat azides and alkynes and a copper(I) polymer supported catalyst (Amberlyst^® A21•CuI) is presented herein. As it provides the products in high yields and purities within minutes, this method thus being characterized as a "flash" synthesis, and was exemplified through the synthesis of a 24-compound library on a small scale.

Keywords: Click chemistry; Huisgen’s cycloaddition; Copper (I) catalysis; Triazoles; Supported catalyst; Solvent-free

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