Next Article in Journal
Previous Article in Journal
Molecules 2009, 14(1), 528-539; doi:10.3390/molecules14010528
Communication

“Flash” Solvent-free Synthesis of Triazoles Using a Supported Catalyst

1,2
, 2
, 1
 and 1,*
Received: 8 January 2009; in revised form: 20 January 2009 / Accepted: 22 January 2009 / Published: 22 January 2009
Download PDF [231 KB, uploaded 18 June 2014]
Abstract: A solvent-free synthesis of 1,4-disubstituted-1,2,3-triazoles using neat azides and alkynes and a copper(I) polymer supported catalyst (Amberlyst® A21•CuI) is presented herein. As it provides the products in high yields and purities within minutes, this method thus being characterized as a "flash" synthesis, and was exemplified through the synthesis of a 24-compound library on a small scale.
Keywords: Click chemistry; Huisgen’s cycloaddition; Copper (I) catalysis; Triazoles; Supported catalyst; Solvent-free Click chemistry; Huisgen’s cycloaddition; Copper (I) catalysis; Triazoles; Supported catalyst; Solvent-free
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Jlalia, I.; Meganem, F.; Herscovici, J.; Girard, C. “Flash” Solvent-free Synthesis of Triazoles Using a Supported Catalyst. Molecules 2009, 14, 528-539.

AMA Style

Jlalia I, Meganem F, Herscovici J, Girard C. “Flash” Solvent-free Synthesis of Triazoles Using a Supported Catalyst. Molecules. 2009; 14(1):528-539.

Chicago/Turabian Style

Jlalia, Ibtissem; Meganem, Faouzi; Herscovici, Jean; Girard, Christian. 2009. "“Flash” Solvent-free Synthesis of Triazoles Using a Supported Catalyst." Molecules 14, no. 1: 528-539.



Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert