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“Flash” Solvent-free Synthesis of Triazoles Using a Supported Catalyst
Laboratoire de Pharmacologie Chimique et Génétique UMR8151 CNRS - U640 INSERM – IFR2769, Ecole Nationale Supérieure de Chimie de Paris, 11, rue Pierre et Marie Curie, 75005 Paris, France
Laboratoire de Synthèse Organique et Application, Faculté des Sciences de Bizerte, Université du 7 Novembre à Carthage, 7021 Jarzouna Bizerte, Tunisia
* Author to whom correspondence should be addressed.
Received: 8 January 2009; in revised form: 20 January 2009 / Accepted: 22 January 2009 / Published: 22 January 2009
Abstract: A solvent-free synthesis of 1,4-disubstituted-1,2,3-triazoles using neat azides and alkynes and a copper(I) polymer supported catalyst (Amberlyst® A21•CuI) is presented herein. As it provides the products in high yields and purities within minutes, this method thus being characterized as a "flash" synthesis, and was exemplified through the synthesis of a 24-compound library on a small scale.
Keywords: Click chemistry; Huisgen’s cycloaddition; Copper (I) catalysis; Triazoles; Supported catalyst; Solvent-free
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Cite This Article
MDPI and ACS Style
Jlalia, I.; Meganem, F.; Herscovici, J.; Girard, C. “Flash” Solvent-free Synthesis of Triazoles Using a Supported Catalyst. Molecules 2009, 14, 528-539.
Jlalia I, Meganem F, Herscovici J, Girard C. “Flash” Solvent-free Synthesis of Triazoles Using a Supported Catalyst. Molecules. 2009; 14(1):528-539.
Jlalia, Ibtissem; Meganem, Faouzi; Herscovici, Jean; Girard, Christian. 2009. "“Flash” Solvent-free Synthesis of Triazoles Using a Supported Catalyst." Molecules 14, no. 1: 528-539.