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Molecules 2009, 14(1), 519-527; doi:10.3390/molecules14010519
Article

Antimicrobial Activity of Some Thiourea Derivatives and Their Nickel and Copper Complexes

1,2,* , 3
,
4
,
2 and 1
1 Department of Natural Sciences, Fayetteville State University, Fayetteville, NC 28301, USA 2 Department of Chemistry, Faculty of Pharmacy, Mersin University, Mersin, TR 33169, Turkey 3 Department of Microbiology, Faculty of Medicine, Mustafa Kemal University, Hatay, TR 31040, Turkey 4 Health School, Mersin University, Mersin, TR 33169, Turkey
* Author to whom correspondence should be addressed.
Received: 2 December 2008 / Revised: 24 December 2008 / Accepted: 5 January 2009 / Published: 22 January 2009
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Abstract

Five thiourea derivative ligands and their Ni2+ and Cu2+ complexes have been synthesized. The compounds were screened for their in vitro anti-bacterial activity using Gram-positive bacteria (two different standard strains of Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, Streptococcus pyogenes, Bacillus cereus) and Gram-negative bacteria (Esherichia coli, Pseudomonas aeruginosa, Enterobacter cloacae, Proteus vulgaris, Enterobacter aerogenes) and in vitro anti-yeast activity (Candida albicans, Candida krusei, Candida glabrata, Candida tropicalis, Candida parapsilosis). The minimum inhibitory concentration was determined for all ligands and their complexes. In vitro anti-yeast activity of both ligands and their metal complexes is greater than their in vitro anti-bacterial activity. The effect of the structure of the investigated compounds on the antimicrobial activity is discussed.
Keywords: Thiourea derivatives; Complexes; Antibacterial activity; Antifungal activity; In vitro studies; Lipophilicity Thiourea derivatives; Complexes; Antibacterial activity; Antifungal activity; In vitro studies; Lipophilicity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Arslan, H.; Duran, N.; Borekci, G.; Koray Ozer, C.; Akbay, C. Antimicrobial Activity of Some Thiourea Derivatives and Their Nickel and Copper Complexes. Molecules 2009, 14, 519-527.

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