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Antimicrobial Activity of Some Thiourea Derivatives and Their Nickel and Copper Complexes
Department of Natural Sciences, Fayetteville State University, Fayetteville, NC 28301, USA
Department of Chemistry, Faculty of Pharmacy, Mersin University, Mersin, TR 33169, Turkey
Department of Microbiology, Faculty of Medicine, Mustafa Kemal University, Hatay, TR 31040, Turkey
Health School, Mersin University, Mersin, TR 33169, Turkey
* Author to whom correspondence should be addressed.
Received: 2 December 2008; in revised form: 24 December 2008 / Accepted: 5 January 2009 / Published: 22 January 2009
Abstract: Five thiourea derivative ligands and their Ni2+ and Cu2+ complexes have been synthesized. The compounds were screened for their in vitro anti-bacterial activity using Gram-positive bacteria (two different standard strains of Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, Streptococcus pyogenes, Bacillus cereus) and Gram-negative bacteria (Esherichia coli, Pseudomonas aeruginosa, Enterobacter cloacae, Proteus vulgaris, Enterobacter aerogenes) and in vitro anti-yeast activity (Candida albicans, Candida krusei, Candida glabrata, Candida tropicalis, Candida parapsilosis). The minimum inhibitory concentration was determined for all ligands and their complexes. In vitro anti-yeast activity of both ligands and their metal complexes is greater than their in vitro anti-bacterial activity. The effect of the structure of the investigated compounds on the antimicrobial activity is discussed.
Keywords: Thiourea derivatives; Complexes; Antibacterial activity; Antifungal activity; In vitro studies; Lipophilicity
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Arslan, H.; Duran, N.; Borekci, G.; Koray Ozer, C.; Akbay, C. Antimicrobial Activity of Some Thiourea Derivatives and Their Nickel and Copper Complexes. Molecules 2009, 14, 519-527.
Arslan H, Duran N, Borekci G, Koray Ozer C, Akbay C. Antimicrobial Activity of Some Thiourea Derivatives and Their Nickel and Copper Complexes. Molecules. 2009; 14(1):519-527.
Arslan, Hakan; Duran, Nizami; Borekci, Gulay; Koray Ozer, Cemal; Akbay, Cevdet. 2009. "Antimicrobial Activity of Some Thiourea Derivatives and Their Nickel and Copper Complexes." Molecules 14, no. 1: 519-527.