Abstract: Five thiourea derivative ligands and their Ni2+ and Cu2+ complexes have been synthesized. The compounds were screened for their in vitro anti-bacterial activity using Gram-positive bacteria (two different standard strains of Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, Streptococcus pyogenes, Bacillus cereus) and Gram-negative bacteria (Esherichia coli, Pseudomonas aeruginosa, Enterobacter cloacae, Proteus vulgaris, Enterobacter aerogenes) and in vitro anti-yeast activity (Candida albicans, Candida krusei, Candida glabrata, Candida tropicalis, Candida parapsilosis). The minimum inhibitory concentration was determined for all ligands and their complexes. In vitro anti-yeast activity of both ligands and their metal complexes is greater than their in vitro anti-bacterial activity. The effect of the structure of the investigated compounds on the antimicrobial activity is discussed.
Keywords: Thiourea derivatives; Complexes; Antibacterial activity; Antifungal activity; In vitro studies; Lipophilicity
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Arslan, H.; Duran, N.; Borekci, G.; Koray Ozer, C.; Akbay, C. Antimicrobial Activity of Some Thiourea Derivatives and Their Nickel and Copper Complexes. Molecules 2009, 14, 519-527.
Arslan H, Duran N, Borekci G, Koray Ozer C, Akbay C. Antimicrobial Activity of Some Thiourea Derivatives and Their Nickel and Copper Complexes. Molecules. 2009; 14(1):519-527.
Arslan, Hakan; Duran, Nizami; Borekci, Gulay; Koray Ozer, Cemal; Akbay, Cevdet. 2009. "Antimicrobial Activity of Some Thiourea Derivatives and Their Nickel and Copper Complexes." Molecules 14, no. 1: 519-527.