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Molecules 2009, 14(1), 403-411; doi:10.3390/molecules14010403
Article

Microwave Assisted Reactions of Some Azaheterocylic Compounds

, , ,  and *
“Al. I. Cuza” University of Iasi, Organic Chemistry Department, Bd. Carol 11, 700506 Iasi, Romania
* Author to whom correspondence should be addressed.
Received: 23 November 2008 / Revised: 12 January 2009 / Accepted: 15 January 2009 / Published: 15 January 2009
(This article belongs to the Special Issue Microwave Assisted Synthesis)
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Abstract

A fast, general, environmentally friendly and facile method for preparation of five- and six-membered ring diazaheterocylic salts under microwave irradiation is presented. The N-alkylation reactions of imidazole, pyrimidine, pyridazine and phthalazine have been studied. The microwaves remarkably accelerated these N-alkylations, the reaction times decreased dramatically, the reaction conditions were milder, the consumed energy decreased considerably and the amount of solvents used was reduced substantially. Consequently, the microwave assisted alkylation of N-containing heterocycles could be considered eco-friendly. In some cases, under MW irradiation the yields are also higher. A comparative study of microwave vs. classical conditions (liquid solvents) has been done. Twelve new diazaheterocylic salts of potential practical interest were obtained.
Keywords: Microwave N-alkylation; Imidazole; Pyrimidine; Pyridazine; Phthalazine Microwave N-alkylation; Imidazole; Pyrimidine; Pyridazine; Phthalazine
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Zbancioc, G.; Bejan, V.; Risca, M.; Moldoveanu, C.; Mangalagiu, I.I. Microwave Assisted Reactions of Some Azaheterocylic Compounds. Molecules 2009, 14, 403-411.

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