Microwave Assisted Reactions of Some Azaheterocylic Compounds
AbstractA fast, general, environmentally friendly and facile method for preparation of five- and six-membered ring diazaheterocylic salts under microwave irradiation is presented. The N-alkylation reactions of imidazole, pyrimidine, pyridazine and phthalazine have been studied. The microwaves remarkably accelerated these N-alkylations, the reaction times decreased dramatically, the reaction conditions were milder, the consumed energy decreased considerably and the amount of solvents used was reduced substantially. Consequently, the microwave assisted alkylation of N-containing heterocycles could be considered eco-friendly. In some cases, under MW irradiation the yields are also higher. A comparative study of microwave vs. classical conditions (liquid solvents) has been done. Twelve new diazaheterocylic salts of potential practical interest were obtained.
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Zbancioc, G.; Bejan, V.; Risca, M.; Moldoveanu, C.; Mangalagiu, I.I. Microwave Assisted Reactions of Some Azaheterocylic Compounds. Molecules 2009, 14, 403-411.
Zbancioc G, Bejan V, Risca M, Moldoveanu C, Mangalagiu II. Microwave Assisted Reactions of Some Azaheterocylic Compounds. Molecules. 2009; 14(1):403-411.Chicago/Turabian Style
Zbancioc, Gheorghita; Bejan, Vasilichia; Risca, Marian; Moldoveanu, Costel; Mangalagiu, Ionel I. 2009. "Microwave Assisted Reactions of Some Azaheterocylic Compounds." Molecules 14, no. 1: 403-411.