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Molecules 2009, 14(1), 403-411; doi:10.3390/molecules14010403
Article

Microwave Assisted Reactions of Some Azaheterocylic Compounds

, , ,  and *
Received: 23 November 2008; in revised form: 12 January 2009 / Accepted: 15 January 2009 / Published: 15 January 2009
(This article belongs to the Special Issue Microwave Assisted Synthesis)
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Abstract: A fast, general, environmentally friendly and facile method for preparation of five- and six-membered ring diazaheterocylic salts under microwave irradiation is presented. The N-alkylation reactions of imidazole, pyrimidine, pyridazine and phthalazine have been studied. The microwaves remarkably accelerated these N-alkylations, the reaction times decreased dramatically, the reaction conditions were milder, the consumed energy decreased considerably and the amount of solvents used was reduced substantially. Consequently, the microwave assisted alkylation of N-containing heterocycles could be considered eco-friendly. In some cases, under MW irradiation the yields are also higher. A comparative study of microwave vs. classical conditions (liquid solvents) has been done. Twelve new diazaheterocylic salts of potential practical interest were obtained.
Keywords: Microwave N-alkylation; Imidazole; Pyrimidine; Pyridazine; Phthalazine Microwave N-alkylation; Imidazole; Pyrimidine; Pyridazine; Phthalazine
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Zbancioc, G.; Bejan, V.; Risca, M.; Moldoveanu, C.; Mangalagiu, I.I. Microwave Assisted Reactions of Some Azaheterocylic Compounds. Molecules 2009, 14, 403-411.

AMA Style

Zbancioc G, Bejan V, Risca M, Moldoveanu C, Mangalagiu II. Microwave Assisted Reactions of Some Azaheterocylic Compounds. Molecules. 2009; 14(1):403-411.

Chicago/Turabian Style

Zbancioc, Gheorghita; Bejan, Vasilichia; Risca, Marian; Moldoveanu, Costel; Mangalagiu, Ionel I. 2009. "Microwave Assisted Reactions of Some Azaheterocylic Compounds." Molecules 14, no. 1: 403-411.


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