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Vitamin B6: A Long Known Compound of Surprising Complexity
School of Biological Sciences, Washington State University, Pullman, WA, USA
Angewandte Genetik, Freie Universität Berlin, 14195 Berlin, Germany
These authors contributed equally to this work
* Author to whom correspondence should be addressed.
Received: 17 December 2008; in revised form: 7 January 2009 / Accepted: 9 January 2009 / Published: 12 January 2009
Abstract: In recent years vitamin B6 has become a focus of research describing the compound’s critical function in cellular metabolism and stress response. For many years the sole function of vitamin B6 was considered to be that of an enzymatic cofactor. However, recently it became clear that it is also a potent antioxidant that effectively quenches reactive oxygen species and is thus of high importance for cellular well-being. In view of the recent findings, the current review takes a look back and summarizes the discovery of vitamin B6 and the elucidation of its structure and biosynthetic pathways. It provides a detailed overview on vitamin B6 both as a cofactor and a protective compound. Besides these general characteristics of the vitamin, the review also outlines the current literature on vitamin B6 derivatives and elaborates on recent findings that provide new insights into transport and catabolism of the compound and on its impact on human health.
Keywords: Pyridoxal phosphate; Vitamin B6; Oxidative stress; Derivatives; Transporter
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MDPI and ACS Style
Mooney, S.; Leuendorf, J.-E.; Hendrickson, C.; Hellmann, H. Vitamin B6: A Long Known Compound of Surprising Complexity. Molecules 2009, 14, 329-351.
Mooney S, Leuendorf J-E, Hendrickson C, Hellmann H. Vitamin B6: A Long Known Compound of Surprising Complexity. Molecules. 2009; 14(1):329-351.
Mooney, Sutton; Leuendorf, Jan-Erik; Hendrickson, Christopher; Hellmann, Hanjo. 2009. "Vitamin B6: A Long Known Compound of Surprising Complexity." Molecules 14, no. 1: 329-351.