Next Article in Journal
Synthesis and Analysis of Resorcinol-Acetone Copolymer
Previous Article in Journal
Vitamin B6: A Long Known Compound of Surprising Complexity
Article Menu

Export Article

Open AccessArticle
Molecules 2009, 14(1), 352-363; doi:10.3390/molecules14010352

Parallel Synthesis of a Library of Symmetrically- and Dissymmetrically-disubstituted Imidazole-4,5-dicarboxamides Bearing Amino Acid Esters

Department of Chemistry and Biochemistry, The University of Tulsa, 800 South Tucker Drive, Tulsa, Oklahoma, USA
*
Author to whom correspondence should be addressed.
Received: 20 November 2008 / Revised: 7 January 2009 / Accepted: 12 January 2009 / Published: 13 January 2009
View Full-Text   |   Download PDF [73 KB, uploaded 18 June 2014]   |  

Abstract

The imidazole-4,5-dicarboxylic acid scaffold is readily derivatized with amino acid esters to afford symmetrically- and dissymmetrically-disubstituted imidazole-4,5-dicarboxamides with intramolecularly hydrogen bonded conformations that predispose the presentation of amino acid pharmacophores. In this work, a total of 45 imidazole-4,5-dicarboxamides bearing amino acid esters were prepared by parallel synthesis. The library members were purified by column chromatography on silica gel and the purified compounds characterized by LC-MS with LC detection at 214 nm. A selection of the final compounds was also analyzed by 1H-NMR spectroscopy. The analytically pure final products have been submitted to the Molecular Library Small Molecule Repository (MLSMR) for screening in the Molecular Library Screening Center Network (MLSCN) as part of the NIH Roadmap.
Keywords: Imidazole; NIH Roadmap; Heterocyclic scaffold; Drug discovery Imidazole; NIH Roadmap; Heterocyclic scaffold; Drug discovery
Figures

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Supplementary materials

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Solinas, R.; DiCesare, J.C.; Baures, P.W. Parallel Synthesis of a Library of Symmetrically- and Dissymmetrically-disubstituted Imidazole-4,5-dicarboxamides Bearing Amino Acid Esters. Molecules 2009, 14, 352-363.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top