Molecules 2008, 13(4), 995-1003; doi:10.3390/molecules13040995
Article

Novel Spiroannulated 3-Benzofuranones. Synthesis and Inhibition of the Human Peptidyl Prolyl cis/trans Isomerase Pin1

1,* email, 1, 1, 2 and 2
Received: 3 April 2008; in revised form: 22 April 2007 / Accepted: 23 April 2008 / Published: 29 April 2008
(This article belongs to the Special Issue Spiro Compounds)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The novel 3H-spiro[1-benzofuran-2-cyclopentan]-3-one skeleton has been madeaccessible by different routes. One- and two-step protocols lead to tricyclic and tetracyclicbenzofuranones 2 and 3, respectively. A four-step synthesis to spirocompound 4 isdescribed. The novel spirocyclic benzofuranones display modest to no inhibition of thehuman peptidyl prolyl cis/trans isomerase Pin1.
Keywords: Ketones; lithiation; cyclization; metathesis; spiroannulation
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MDPI and ACS Style

Braun, M.; Hessamian-Alinejad, A.; De Lacroix, B.F.; Alvarez, B.H.; Fischer, G. Novel Spiroannulated 3-Benzofuranones. Synthesis and Inhibition of the Human Peptidyl Prolyl cis/trans Isomerase Pin1. Molecules 2008, 13, 995-1003.

AMA Style

Braun M, Hessamian-Alinejad A, De Lacroix BF, Alvarez BH, Fischer G. Novel Spiroannulated 3-Benzofuranones. Synthesis and Inhibition of the Human Peptidyl Prolyl cis/trans Isomerase Pin1. Molecules. 2008; 13(4):995-1003.

Chicago/Turabian Style

Braun, Manfred; Hessamian-Alinejad, Anahita; De Lacroix, Boris F.; Alvarez, Birte H.; Fischer, Gunter. 2008. "Novel Spiroannulated 3-Benzofuranones. Synthesis and Inhibition of the Human Peptidyl Prolyl cis/trans Isomerase Pin1." Molecules 13, no. 4: 995-1003.

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