Molecules 2008, 13(4), 986-994; doi:10.3390/molecules13040986

Fluorinated Analogs of Malachite Green: Synthesis and Toxicity

1,* email, 1, 2, 2, 2 and 3
Received: 21 March 2008; in revised form: 22 April 2008 / Accepted: 22 April 2008 / Published: 27 April 2008
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: A series of fluorinated analogs of malachite green (MG) have been synthesizedand their toxicity to Saccharomyces cerevisiae and a human ovarian epithelial cell lineexamined. The toxicity profiles were found to be different for these two species. Twoanalogs, one with 2,4-difluoro substitution and the other with 2-fluoro substitution seem tobe the most promising analogs because they showed the lowest toxicity to the human cells.
Keywords: Malachite Green; Malachite Green analogs; Bathochromic shift; Toxicity; Saccharomyces cerevisiae; human ovarian epithelial cells.
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MDPI and ACS Style

Kraus, G.A.; Jeon, I.; Nilsen-Hamilton, M.; Awad, A.M.; Banerjee, J.; Parvin, B. Fluorinated Analogs of Malachite Green: Synthesis and Toxicity. Molecules 2008, 13, 986-994.

AMA Style

Kraus GA, Jeon I, Nilsen-Hamilton M, Awad AM, Banerjee J, Parvin B. Fluorinated Analogs of Malachite Green: Synthesis and Toxicity. Molecules. 2008; 13(4):986-994.

Chicago/Turabian Style

Kraus, George A.; Jeon, Insik; Nilsen-Hamilton, Marit; Awad, Ahmed M.; Banerjee, Jayeeta; Parvin, Bahram. 2008. "Fluorinated Analogs of Malachite Green: Synthesis and Toxicity." Molecules 13, no. 4: 986-994.

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