Molecules 2008, 13(4), 716-728; doi:10.3390/molecules13040716
Article

An Efficient Synthesis of γ-Aminoacids and Attempts to Drive Its Enantioselectivity

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Received: 10 March 2008; in revised form: 26 March 2008 / Accepted: 26 March 2008 / Published: 27 March 2008
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Addition of carboxylic acid dianions to bromoacetonitrile lead, in good yields,to the corresponding γ-cyanoacids, which on hydrogenation yielded γ-aminoacids. Thistwo step methodology improves upon previously described results. Poor e.e’s resultedfrom our attempts to drive the enantioselectivity of this transformation by chiral amideinduction.
Keywords: GABA; γ-aminoacids; bromoacetonitrile; enediolate; regioselectivity.
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MDPI and ACS Style

Gil, S.; Parra, M.; Rodríguez, P. An Efficient Synthesis of γ-Aminoacids and Attempts to Drive Its Enantioselectivity. Molecules 2008, 13, 716-728.

AMA Style

Gil S, Parra M, Rodríguez P. An Efficient Synthesis of γ-Aminoacids and Attempts to Drive Its Enantioselectivity. Molecules. 2008; 13(4):716-728.

Chicago/Turabian Style

Gil, Salvador; Parra, Margarita; Rodríguez, Pablo. 2008. "An Efficient Synthesis of γ-Aminoacids and Attempts to Drive Its Enantioselectivity." Molecules 13, no. 4: 716-728.

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