Next Article in Journal
Three New Caffeoyl Glycosides from the Roots of Picrorhiza Scrophulariiflora
Previous Article in Journal
Synthesis of Polynucleotide Analogs Containing a Polyvinyl Alcohol Backbone
Molecules 2008, 13(4), 716-728; doi:10.3390/molecules13040716

An Efficient Synthesis of γ-Aminoacids and Attempts to Drive Its Enantioselectivity

*  and
Department de Organic Chemistry, Universitat de València, Dr. Moliner 50, 46100 Burjassot, Spain
* Author to whom correspondence should be addressed.
Received: 10 March 2008 / Revised: 26 March 2008 / Accepted: 26 March 2008 / Published: 27 March 2008
View Full-Text   |   Download PDF [74 KB, uploaded 18 June 2014]   |   Browse Figures


Addition of carboxylic acid dianions to bromoacetonitrile lead, in good yields,to the corresponding γ-cyanoacids, which on hydrogenation yielded γ-aminoacids. Thistwo step methodology improves upon previously described results. Poor e.e’s resultedfrom our attempts to drive the enantioselectivity of this transformation by chiral amideinduction.
Keywords: GABA; γ-aminoacids; bromoacetonitrile; enediolate; regioselectivity. GABA; γ-aminoacids; bromoacetonitrile; enediolate; regioselectivity.
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
MDPI and ACS Style

Gil, S.; Parra, M.; Rodríguez, P. An Efficient Synthesis of γ-Aminoacids and Attempts to Drive Its Enantioselectivity. Molecules 2008, 13, 716-728.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert