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Molecules 2008, 13(3), 701-715; doi:10.3390/molecules13030701

Synthesis of Polynucleotide Analogs Containing a Polyvinyl Alcohol Backbone

Department of Chemistry, Norwegian University of Science and Technology-NTNU, N-7491 Trondheim, Norway
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Author to whom correspondence should be addressed.
Received: 21 February 2008 / Accepted: 10 March 2008 / Published: 26 March 2008
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Abstract

Water soluble homo-base polynucleotide analogues were synthesized in whichpolyvinyl alcohol and partially phosphonated polyvinyl alcohol constituted the backbones,onto which were grafted uracil or adenine via 1,3-dioxane spacers formed by acetalformation with the 1,3-diol moieties in PVA. The resulting adenine-PVA polynucleotideanalogs exhibited hyperchromic effects, which was not the case for the correspondinguracil compounds. Mixtures of the adenine- and aracil PVA-phosphate polynucleotideanalogs in solutions exhibited characteristic S-shaped UV-absorbance vs temperature andmelting curves with melting points at approximately 40 oC.
Keywords: Polynucleotide; Nucleoside; Polymer; PVA Polynucleotide; Nucleoside; Polymer; PVA
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Yu, Q.; Carlsen, P. Synthesis of Polynucleotide Analogs Containing a Polyvinyl Alcohol Backbone. Molecules 2008, 13, 701-715.

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