Next Article in Journal
An Efficient Synthesis of γ-Aminoacids and Attempts to Drive Its Enantioselectivity
Previous Article in Journal
New Cleft-like Molecules and Macrocycles from Phosphonate Substituted Spirobisindanol
Molecules 2008, 13(3), 701-715; doi:10.3390/molecules13030701

Synthesis of Polynucleotide Analogs Containing a Polyvinyl Alcohol Backbone

 and *
Department of Chemistry, Norwegian University of Science and Technology-NTNU, N-7491 Trondheim, Norway
* Author to whom correspondence should be addressed.
Received: 21 February 2008 / Accepted: 10 March 2008 / Published: 26 March 2008
View Full-Text   |   Download PDF [157 KB, uploaded 18 June 2014]   |   Browse Figures


Water soluble homo-base polynucleotide analogues were synthesized in whichpolyvinyl alcohol and partially phosphonated polyvinyl alcohol constituted the backbones,onto which were grafted uracil or adenine via 1,3-dioxane spacers formed by acetalformation with the 1,3-diol moieties in PVA. The resulting adenine-PVA polynucleotideanalogs exhibited hyperchromic effects, which was not the case for the correspondinguracil compounds. Mixtures of the adenine- and aracil PVA-phosphate polynucleotideanalogs in solutions exhibited characteristic S-shaped UV-absorbance vs temperature andmelting curves with melting points at approximately 40 oC.
Keywords: Polynucleotide; Nucleoside; Polymer; PVA Polynucleotide; Nucleoside; Polymer; PVA
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
MDPI and ACS Style

Yu, Q.; Carlsen, P. Synthesis of Polynucleotide Analogs Containing a Polyvinyl Alcohol Backbone. Molecules 2008, 13, 701-715.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert