Molecules 2008, 13(3), 701-715; doi:10.3390/molecules13030701
Article

Synthesis of Polynucleotide Analogs Containing a Polyvinyl Alcohol Backbone

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Received: 21 February 2008; Accepted: 10 March 2008 / Published: 26 March 2008
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Water soluble homo-base polynucleotide analogues were synthesized in whichpolyvinyl alcohol and partially phosphonated polyvinyl alcohol constituted the backbones,onto which were grafted uracil or adenine via 1,3-dioxane spacers formed by acetalformation with the 1,3-diol moieties in PVA. The resulting adenine-PVA polynucleotideanalogs exhibited hyperchromic effects, which was not the case for the correspondinguracil compounds. Mixtures of the adenine- and aracil PVA-phosphate polynucleotideanalogs in solutions exhibited characteristic S-shaped UV-absorbance vs temperature andmelting curves with melting points at approximately 40 oC.
Keywords: Polynucleotide; Nucleoside; Polymer; PVA
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MDPI and ACS Style

Yu, Q.; Carlsen, P. Synthesis of Polynucleotide Analogs Containing a Polyvinyl Alcohol Backbone. Molecules 2008, 13, 701-715.

AMA Style

Yu Q, Carlsen P. Synthesis of Polynucleotide Analogs Containing a Polyvinyl Alcohol Backbone. Molecules. 2008; 13(3):701-715.

Chicago/Turabian Style

Yu, Qiang; Carlsen, Per. 2008. "Synthesis of Polynucleotide Analogs Containing a Polyvinyl Alcohol Backbone." Molecules 13, no. 3: 701-715.

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