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Molecules 2008, 13(4), 1011-1024; doi:10.3390/molecules13041011
Article

Synthesis and Biological Activity of Some New Pyrazoline and Pyrrolo[3,4-c]pyrazole-4,6-dione Derivatives: Reaction of Nitrilimines with Some Dipolarophiles

1,* , 2
,
3
 and
1
1 Department of Chemistry, Faculty of Applied Sciences, Al-Aqsa University, 76888 Gaza, Palestine 2 Department of Chemistry, Faculty of Science, Cairo University, Egypt 3 Department of Chemistry, University College for Women, Ain Shams University, Heliopolis, Cairo, Egypt
* Author to whom correspondence should be addressed.
Received: 8 April 2008 / Revised: 22 April 2008 / Accepted: 22 April 2008 / Published: 29 April 2008
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Abstract

Several 1,3-diaryl-5-(cyano-, aminocarbonyl- and ethoxycarbonyl-)-2-pyrazoline, pyrrolo[3,4-c]pyrazole-4,6-dione and 1,3,4,5-tetraaryl-2-pyrazoline derivativeswere prepared by the reaction of nitrilimine with different dipolarophilic reagents. The newcompounds were characterized using IR, 1H-NMR, 13C-NMR and mass spectra. Biologicalscreening of some compounds is reported.
Keywords: Pyrazoline; pyrrolo[3; 4-c]pyrazole-4; 6-dione; nitrilimine; dipolarophile; biological activity Pyrazoline; pyrrolo[3; 4-c]pyrazole-4; 6-dione; nitrilimine; dipolarophile; biological activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Abunada, N.M.; Hassaneen, H.M.; Kandile, N.G.; Miqdad, O.A. Synthesis and Biological Activity of Some New Pyrazoline and Pyrrolo[3,4-c]pyrazole-4,6-dione Derivatives: Reaction of Nitrilimines with Some Dipolarophiles. Molecules 2008, 13, 1011-1024.

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