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The Influence of Hofmeister Series Ions on Hyaluronan Swelling and Viscosity
Department of Physics and Materials Engineering, Faculty of Technology, Tomas Bata University in Zlín, Nad Stráněmi 4511, 76005 Zlín, Czech Republic
Medical Materials Research Centre, Technology park, University Institute, Tomas Bata University in Zlín, Nad Ovcirnou III 3685, Zlín, 76001 Czech Republic
CPN Ltd., Dolní Dobrouč 401, 561 02 Dolní Dobrouč, Czech Republic
* Author to whom correspondence should be addressed.
Received: 28 February 2008; in revised form: 17 April 2008 / Accepted: 30 April 2008 / Published: 1 May 2008
Abstract: The dissolution of hyaluronan in water leads to its degradation, and as a resultits molecular weight decreases. The degradation of hyaluronan is mainly influenced bytemperature, solution composition, and also its pH. This study describes the influence ofHofmeister series ions on hyaluronan behaviour and hyaluronan film swelling bysolutions of these ions. It was found that Hofmeister ions show lyotropic effectsinfluencing the entanglement of hyaluronan coils and their expansion from solid polymerfilms into swollen gel state. The hydrophobic and hydrophilic interactions in the structureof hyaluronan macromolecules are represented by the mutual diffusion coefficient D(c),the mean mutual diffusion coefficient Ds , the expansion work of coil swelling RAδ,s, theactivation enthalpy of diffusion connected with swelling HD,s and kinematic viscosity ofhyaluronan-ions solutions ν.
Keywords: Material Science; biomaterials; hyaluronan; Hofmeister series.
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Mráček, A.; Varhaníková, J.; Lehocký, M.; Gřundělová, L.; Pokopcová, A.; Velebný, V. The Influence of Hofmeister Series Ions on Hyaluronan Swelling and Viscosity. Molecules 2008, 13, 1025-1034.
Mráček A, Varhaníková J, Lehocký M, Gřundělová L, Pokopcová A, Velebný V. The Influence of Hofmeister Series Ions on Hyaluronan Swelling and Viscosity. Molecules. 2008; 13(5):1025-1034.
Mráček, Aleš; Varhaníková, Júlia; Lehocký, Marián; Gřundělová, Lenka; Pokopcová, Alena; Velebný, Vladimír. 2008. "The Influence of Hofmeister Series Ions on Hyaluronan Swelling and Viscosity." Molecules 13, no. 5: 1025-1034.