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Enantioselective Synthesis of Homo-N-Nucleosides Containing a 1,4-Dioxane Sugar Analog
Molecules 2008, 13(12), 3092-3106; doi:10.3390/molecules13123092
Article

Synthesis of Novel Homo-N-Nucleoside Analogs Composed of a Homo-1,4-Dioxane Sugar Analog and Substituted 1,3,5-Triazine Base Equivalents

1
, 2, 2 and 1,*
Received: 7 November 2008; in revised form: 21 November 2008 / Accepted: 3 December 2008 / Published: 10 December 2008
(This article belongs to the Special Issue Nucleic Acids)
Download PDF [194 KB, uploaded 18 June 2014]
Abstract: Enantioselective syntheses from dimethyl tartrate of 1,3,5-triazine homo-N-nucleoside analogs, containing a 1,4-dioxane moiety replacing the sugar unit in natural nucleosides, were accomplished. The triazine heterocycle in the nucleoside analogs was further substituted with combinations of NH2, OH and Cl in the 2,4-triazine positions.
Keywords: 1; 3; 5-Triazine; 1; 4-Dioxane; Nucleoside analogue; Heterocycle; Homo-N-nucleoside; Nucleoside analogs 1; 3; 5-Triazine; 1; 4-Dioxane; Nucleoside analogue; Heterocycle; Homo-N-nucleoside; Nucleoside analogs
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Yu, Q.; Schwidom, D.; Exner, A.; Carlsen, P. Synthesis of Novel Homo-N-Nucleoside Analogs Composed of a Homo-1,4-Dioxane Sugar Analog and Substituted 1,3,5-Triazine Base Equivalents. Molecules 2008, 13, 3092-3106.

AMA Style

Yu Q, Schwidom D, Exner A, Carlsen P. Synthesis of Novel Homo-N-Nucleoside Analogs Composed of a Homo-1,4-Dioxane Sugar Analog and Substituted 1,3,5-Triazine Base Equivalents. Molecules. 2008; 13(12):3092-3106.

Chicago/Turabian Style

Yu, Qiang; Schwidom, Dirk; Exner, Alexander; Carlsen, Per. 2008. "Synthesis of Novel Homo-N-Nucleoside Analogs Composed of a Homo-1,4-Dioxane Sugar Analog and Substituted 1,3,5-Triazine Base Equivalents." Molecules 13, no. 12: 3092-3106.


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