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Enantioselective Synthesis of Homo-N-Nucleosides Containing a 1,4-Dioxane Sugar Analog
Molecules 2008, 13(12), 3092-3106; doi:10.3390/molecules13123092
Article

Synthesis of Novel Homo-N-Nucleoside Analogs Composed of a Homo-1,4-Dioxane Sugar Analog and Substituted 1,3,5-Triazine Base Equivalents

1
,
2, 2 and 1,*
1 Department of Chemistry, Norwegian University of Science and Technology (NTNU), N-7491 Trondheim, Norway 2 Socrates exchange student: Department of Chemistry, University of Hamburg, D-20146 Hamburg, Germany
* Author to whom correspondence should be addressed.
Received: 7 November 2008 / Revised: 21 November 2008 / Accepted: 3 December 2008 / Published: 10 December 2008
(This article belongs to the Special Issue Nucleic Acids)
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Abstract

Enantioselective syntheses from dimethyl tartrate of 1,3,5-triazine homo-N-nucleoside analogs, containing a 1,4-dioxane moiety replacing the sugar unit in natural nucleosides, were accomplished. The triazine heterocycle in the nucleoside analogs was further substituted with combinations of NH2, OH and Cl in the 2,4-triazine positions.
Keywords: 1; 3; 5-Triazine; 1; 4-Dioxane; Nucleoside analogue; Heterocycle; Homo-N-nucleoside; Nucleoside analogs 1; 3; 5-Triazine; 1; 4-Dioxane; Nucleoside analogue; Heterocycle; Homo-N-nucleoside; Nucleoside analogs
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Yu, Q.; Schwidom, D.; Exner, A.; Carlsen, P. Synthesis of Novel Homo-N-Nucleoside Analogs Composed of a Homo-1,4-Dioxane Sugar Analog and Substituted 1,3,5-Triazine Base Equivalents. Molecules 2008, 13, 3092-3106.

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