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Molecules 2008, 13(12), 3107-3116; doi:10.3390/molecules13123107
Article

The Effect of Monoterpenes on Swarming Differentiation and Haemolysin Activity in Proteus mirabilis

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Received: 3 November 2008; in revised form: 19 November 2008 / Accepted: 27 November 2008 / Published: 15 December 2008
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Abstract: Urinary tract infection by Proteus mirabilis depends on several virulence properties that are coordinately regulated with swarming differentiation. Here we report the antibacterial and anti-swarming effect of seventeen terpenoids, and the effect of subinhibitory concentrations of five selected terpenoids on swarming, biofilm formation and haemolysin activity. The results showed that all the terpenes evaluated, particularly oxygenated terpenoids, inhibited P. mirabilis with MIC values ranging between 3 and 10 mg/L. Moreover, citral, citronellol and geraniol effectively inhibit P. mirabilis swarming in a dose dependent manner, reducing swimming/swarming cell differentiation and haemolysin activity at 1/10 MIC concentration. The inhibition of P. mirabilis swarming and virulence factor expression by selected oxygenated terpenoids suggest that essential oils with high concentration of these compounds have the potential to be developed as products for preventing P. mirabilis infections.
Keywords: Terpenoids; Cell differentiation; Proteus mirabilis; MIC Terpenoids; Cell differentiation; Proteus mirabilis; MIC
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Echeverrigaray, S.; Michelim, L.; Longaray Delamare, A.P.; Andrade, C.P.; Pinto da Costa, S.O.; Zacaria, J. The Effect of Monoterpenes on Swarming Differentiation and Haemolysin Activity in Proteus mirabilis. Molecules 2008, 13, 3107-3116.

AMA Style

Echeverrigaray S, Michelim L, Longaray Delamare AP, Andrade CP, Pinto da Costa SO, Zacaria J. The Effect of Monoterpenes on Swarming Differentiation and Haemolysin Activity in Proteus mirabilis. Molecules. 2008; 13(12):3107-3116.

Chicago/Turabian Style

Echeverrigaray, Sergio; Michelim, Lessandra; Longaray Delamare, Ana P.; Andrade, Cristiane P.; Pinto da Costa, Sérgio O.; Zacaria, Jucimar. 2008. "The Effect of Monoterpenes on Swarming Differentiation and Haemolysin Activity in Proteus mirabilis." Molecules 13, no. 12: 3107-3116.


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