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A New Cytotoxic Pregnanone from Calotropis gigantea
Institute of Crops Genetic Resources, Chinese Academy of Tropical Agricultural Sciences, Danzhou, 571737, P. R. China
Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, 571101, P. R. China
* Authors to whom correspondence should be addressed.
Received: 25 September 2008; in revised form: 26 November 2008 / Accepted: 3 December 2008 / Published: 4 December 2008
Abstract: A new pregnanone, named calotropone (1), was isolated from the EtOH extract of the roots of Calotropis gigantea L. together with a known cardiac glycoside. The structures were elucidated by a study of their physical and spectral data. Compounds 1 and 2 displayed inhibitory effects towards chronic myelogenous leukemia K562 and human gastric cancer SGC-7901 cell lines.
Keywords: Calotropis gigantea L.; Calotropone; Cytotoxicity
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Cite This Article
MDPI and ACS Style
Wang, Z.-N.; Wang, M.-Y.; Mei, W.-L.; Han, Z.; Dai, H.-F. A New Cytotoxic Pregnanone from Calotropis gigantea. Molecules 2008, 13, 3033-3039.
Wang Z-N, Wang M-Y, Mei W-L, Han Z, Dai H-F. A New Cytotoxic Pregnanone from Calotropis gigantea. Molecules. 2008; 13(12):3033-3039.
Wang, Zhu-Nian; Wang, Mao-Yuan; Mei, Wen-Li; Han, Zhuang; Dai, Hao-Fu. 2008. "A New Cytotoxic Pregnanone from Calotropis gigantea." Molecules 13, no. 12: 3033-3039.