Molecules 2008, 13(12), 3033-3039; doi:10.3390/molecules13123033
Article

A New Cytotoxic Pregnanone from Calotropis gigantea

Zhu-Nian Wang 1,* email, Mao-Yuan Wang 1 email, Wen-Li Mei 2 email, Zhuang Han 2 email and Hao-Fu Dai 1,2,* email
1 Institute of Crops Genetic Resources, Chinese Academy of Tropical Agricultural Sciences, Danzhou, 571737, P. R. China 2 Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, 571101, P. R. China
* Authors to whom correspondence should be addressed.
Received: 25 September 2008; in revised form: 26 November 2008 / Accepted: 3 December 2008 / Published: 4 December 2008
PDF Full-text Download PDF Full-Text [220 KB, uploaded 4 December 2008 12:04 CET]
Abstract: A new pregnanone, named calotropone (1), was isolated from the EtOH extract of the roots of Calotropis gigantea L. together with a known cardiac glycoside. The structures were elucidated by a study of their physical and spectral data. Compounds 1 and 2 displayed inhibitory effects towards chronic myelogenous leukemia K562 and human gastric cancer SGC-7901 cell lines.
Keywords: Calotropis gigantea L.; Calotropone; Cytotoxicity

Correction

Article Statistics

Click here to load and display the download statistics.

Cite This Article

MDPI and ACS Style

Wang, Z.-N.; Wang, M.-Y.; Mei, W.-L.; Han, Z.; Dai, H.-F. A New Cytotoxic Pregnanone from Calotropis gigantea. Molecules 2008, 13, 3033-3039.

AMA Style

Wang Z-N, Wang M-Y, Mei W-L, Han Z, Dai H-F. A New Cytotoxic Pregnanone from Calotropis gigantea. Molecules. 2008; 13(12):3033-3039.

Chicago/Turabian Style

Wang, Zhu-Nian; Wang, Mao-Yuan; Mei, Wen-Li; Han, Zhuang; Dai, Hao-Fu. 2008. "A New Cytotoxic Pregnanone from Calotropis gigantea." Molecules 13, no. 12: 3033-3039.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert