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Bioactive Pentacyclic Triterpenes from the Stems of Combretum laxum
Departamento de Química, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brasil, 79070-900
* Author to whom correspondence should be addressed.
Received: 22 September 2008; in revised form: 16 October 2008 / Accepted: 20 October 2008 / Published: 1 November 2008
Abstract: Two new triterpene glucosides, β-D-glucopyranosyl 2α,3β,24-trihydroxyolean- 12-en-28-oate and β-D-glucopyranosyl 2α,3β,23,24-tetrahydroxyurs-12-en-28-oate, in addition to nine known compounds belonging to three different triterpene classes (oleanane-, ursane- and lupane-type) have been isolated from the stems of a specimen of Combretum laxum growing in the “Pantanal” of the central-western region of Brazil. Among the known triterpenes, β-D-glucopyranosyl 2α,3β,6β-trihydroxyolean-12-en-28-oate is reported for the first time in the Combretaceae, while bellericoside and asiatic acid are described for the first time in the genus Combretum. The structures of the isolated compounds have been established on the basis of spectral techniques (1D-, 2D-NMR and MS). Their in vitro antifungal activities against standard strains of Candida albicans, C. krusei and Cryptococcus neoformans were also evaluated in this work.
Keywords: Combretum laxum; Combretaceae; triterpenes; antifungal activity
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Bisoli, E.; Garcez, W.S.; Hamerski, L.; Tieppo, C.; Garcez, F.R. Bioactive Pentacyclic Triterpenes from the Stems of Combretum laxum. Molecules 2008, 13, 2717-2728.
Bisoli E, Garcez WS, Hamerski L, Tieppo C, Garcez FR. Bioactive Pentacyclic Triterpenes from the Stems of Combretum laxum. Molecules. 2008; 13(11):2717-2728.
Bisoli, Eder; Garcez, Walmir S.; Hamerski, Lidilhone; Tieppo, Caroline; Garcez, Fernanda R. 2008. "Bioactive Pentacyclic Triterpenes from the Stems of Combretum laxum." Molecules 13, no. 11: 2717-2728.