Targeted Synthesis of 1-(4-Hydroxyiminomethylpyridinium)-3-pyridiniumpropane Dibromide – A New Nerve Agent Reactivator
Abstract
:Introduction
Results and Discussion
Nerve agent | ||||
---|---|---|---|---|
tabun | cyclosarin | |||
Oxime | Reactivation potency [%] ± SD | Reactivation potency [%] ± SD | ||
10-5 M | 10-3 M | 10-5 M | 10-3 M | |
pralidoxime (1) | 0 | 4 ± 0 | 0 | 4 ± 0 |
HI-6 (2) | 4 ± 0 | 2 ± 0 | 71 ± 3 | 70 ± 3 |
obidoxime (3) | 3 ± 0 | 25 ± 1 | 2 ± 0 | 4 ± 0 |
trimedoxime (4) | 6 ± 0 | 41 ± 2 | 0 | 0 |
K027 (5) | 1 ± 0 | 11 ± 0 | 0 | 0 |
6 | 13 ± 0 | 13 ± 0 | 20 ± 1 | 21 ± 1 |
Conclusions
Experimental
General
Synthesis
Characterization data
Biological activity
Acknowledgements
References and Notes
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Kuca, K.; Musilek, K.; Paar, M.; Jun, D.; Stodulka, P.; Hrabinova, M.; Marek, J. Targeted Synthesis of 1-(4-Hydroxyiminomethylpyridinium)-3-pyridiniumpropane Dibromide – A New Nerve Agent Reactivator. Molecules 2007, 12, 1964-1972. https://doi.org/10.3390/12081964
Kuca K, Musilek K, Paar M, Jun D, Stodulka P, Hrabinova M, Marek J. Targeted Synthesis of 1-(4-Hydroxyiminomethylpyridinium)-3-pyridiniumpropane Dibromide – A New Nerve Agent Reactivator. Molecules. 2007; 12(8):1964-1972. https://doi.org/10.3390/12081964
Chicago/Turabian StyleKuca, Kamil, Kamil Musilek, Martin Paar, Daniel Jun, Petr Stodulka, Martina Hrabinova, and Jan Marek. 2007. "Targeted Synthesis of 1-(4-Hydroxyiminomethylpyridinium)-3-pyridiniumpropane Dibromide – A New Nerve Agent Reactivator" Molecules 12, no. 8: 1964-1972. https://doi.org/10.3390/12081964