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Molecules 2007, 12(8), 1964-1972; doi:10.3390/12081964
Communication

Targeted Synthesis of 1-(4-Hydroxyiminomethylpyridinium)-3-pyridiniumpropane Dibromide – A New Nerve Agent Reactivator

1, 2,* , 3, 1, 1, 1 and 2
1 Center of Advanced Studies, Faculty of Military Health Sciences, Hradec Kralove, Czech Republic 2 Department of Toxicology, Faculty of Military Health Sciences, Hradec Kralove, Czech Republic 3 Department of Pharmaceutical Chemistry and Drug Control, Faculty of Pharmacy, Hradec Kralove, Czech Republic
* Author to whom correspondence should be addressed.
Received: 31 July 2007 / Revised: 14 August 2007 / Accepted: 14 August 2007 / Published: 20 August 2007
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Abstract

Preparation of 1-(4-hydroxy-iminomethylpyridinium)-3-pyridiniumpropane dibromide is described. This compound represents a new acetylcholinesterase (AChE) reactivator, which has no substituents on the second pyridinium ring as found in other commonly used AChE reactivators. The reactivation ability of this reactivator was tested on tabun- and cyclosarin-inhibited AChE. According to the results obtained, the new compound (without substitution and with decreased molecule size) showed increased reactivation potency in case of cyclosarin inhibited AChE. A potent oxime for treatment of tabun and cyclosarin-caused intoxications was thus obtained via slight modification of the reactivator structure (compared to trimedoxime and K027).
Keywords: Acetylcholinesterase; reactivator; nerve agent; broad-spectrum reactivator. Acetylcholinesterase; reactivator; nerve agent; broad-spectrum reactivator.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Kuca, K.; Musilek, K.; Paar, M.; Jun, D.; Stodulka, P.; Hrabinova, M.; Marek, J. Targeted Synthesis of 1-(4-Hydroxyiminomethylpyridinium)-3-pyridiniumpropane Dibromide – A New Nerve Agent Reactivator. Molecules 2007, 12, 1964-1972.

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