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Molecules 2007, 12(6), 1210-1219; doi:10.3390/12061210
Article

Antiradical Activity of Paulownia tomentosa (Scrophulariaceae) Extracts

1,* , 1
,
1
,
2
 and
1
1 Natural Drugs Department, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Palackého 1-3, CZ-612 42 Brno, Czech Republic 2 Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Palackého 1-3, CZ-612 42 Brno, Czech Republic
* Author to whom correspondence should be addressed.
Received: 27 May 2007 / Revised: 21 June 2007 / Accepted: 25 June 2007 / Published: 27 June 2007
(This article belongs to the Special Issue Phenolics and Polyphenolics)
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Abstract

Paulownia tomentosa is a large indecidous tree planted mostly for its fast growing wood and decoratative purposes. The tree is also used in traditional Chinese medicine. As a part of our study of natural polyphenols, the fruits of Paulownia tomentosa were extracted by EtOH and than subjected to liquid/liquid extraction. Fractions were analysed by TLC and HPLC to determine presence of phenolic substantaces. We identified and quantified acteoside (1) and isoacteoside (2) in the EtOAc and n-BuOH extracts; mimulone (3) and diplacone (4) in the MeOH extract. To determine the antiradical activity of extracts we used the anti DPPH and peroxynitrite assays. The activity was expressed as Trolox C equivalents, IC50 for DPPH scavenging and a time dependency course was established. The polyphenols content was determined; results were expressed as gallic acid equivalents. Using these methods we found the fractions of the n-BuOH, EtOAc and MeOH extracts that display antiradical activity, which could be exploited as potential pharmaceuticals.
Keywords: Paulownia tomentosa; antioxidant; DPPH; antiperoxynitrite; phenolics Paulownia tomentosa; antioxidant; DPPH; antiperoxynitrite; phenolics
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Smejkal, K.; Holubova, P.; Zima, A.; Muselik, J.; Dvorska, M. Antiradical Activity of Paulownia tomentosa (Scrophulariaceae) Extracts. Molecules 2007, 12, 1210-1219.

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