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Molecules 2007, 12(6), 1210-1219; doi:10.3390/12061210
Article

Antiradical Activity of Paulownia tomentosa (Scrophulariaceae) Extracts

1,* , 1
,
1
,
2
 and
1
1 Natural Drugs Department, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Palackého 1-3, CZ-612 42 Brno, Czech Republic 2 Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Palackého 1-3, CZ-612 42 Brno, Czech Republic
* Author to whom correspondence should be addressed.
Received: 27 May 2007 / Revised: 21 June 2007 / Accepted: 25 June 2007 / Published: 27 June 2007
(This article belongs to the Special Issue Phenolics and Polyphenolics)
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Abstract

Paulownia tomentosa is a large indecidous tree planted mostly for its fast growing wood and decoratative purposes. The tree is also used in traditional Chinese medicine. As a part of our study of natural polyphenols, the fruits of Paulownia tomentosa were extracted by EtOH and than subjected to liquid/liquid extraction. Fractions were analysed by TLC and HPLC to determine presence of phenolic substantaces. We identified and quantified acteoside (1) and isoacteoside (2) in the EtOAc and n-BuOH extracts; mimulone (3) and diplacone (4) in the MeOH extract. To determine the antiradical activity of extracts we used the anti DPPH and peroxynitrite assays. The activity was expressed as Trolox C equivalents, IC50 for DPPH scavenging and a time dependency course was established. The polyphenols content was determined; results were expressed as gallic acid equivalents. Using these methods we found the fractions of the n-BuOH, EtOAc and MeOH extracts that display antiradical activity, which could be exploited as potential pharmaceuticals.
Keywords: Paulownia tomentosa; antioxidant; DPPH; antiperoxynitrite; phenolics Paulownia tomentosa; antioxidant; DPPH; antiperoxynitrite; phenolics
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Smejkal, K.; Holubova, P.; Zima, A.; Muselik, J.; Dvorska, M. Antiradical Activity of Paulownia tomentosa (Scrophulariaceae) Extracts. Molecules 2007, 12, 1210-1219.

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