Antiradical Activity of Paulownia tomentosa (Scrophulariaceae) Extracts
AbstractPaulownia tomentosa is a large indecidous tree planted mostly for its fast growing wood and decoratative purposes. The tree is also used in traditional Chinese medicine. As a part of our study of natural polyphenols, the fruits of Paulownia tomentosa were extracted by EtOH and than subjected to liquid/liquid extraction. Fractions were analysed by TLC and HPLC to determine presence of phenolic substantaces. We identified and quantified acteoside (1) and isoacteoside (2) in the EtOAc and n-BuOH extracts; mimulone (3) and diplacone (4) in the MeOH extract. To determine the antiradical activity of extracts we used the anti DPPH and peroxynitrite assays. The activity was expressed as Trolox C equivalents, IC50 for DPPH scavenging and a time dependency course was established. The polyphenols content was determined; results were expressed as gallic acid equivalents. Using these methods we found the fractions of the n-BuOH, EtOAc and MeOH extracts that display antiradical activity, which could be exploited as potential pharmaceuticals.
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Smejkal, K.; Holubova, P.; Zima, A.; Muselik, J.; Dvorska, M. Antiradical Activity of Paulownia tomentosa (Scrophulariaceae) Extracts. Molecules 2007, 12, 1210-1219.
Smejkal K, Holubova P, Zima A, Muselik J, Dvorska M. Antiradical Activity of Paulownia tomentosa (Scrophulariaceae) Extracts. Molecules. 2007; 12(6):1210-1219.Chicago/Turabian Style
Smejkal, Karel; Holubova, Pavla; Zima, Ales; Muselik, Jan; Dvorska, Margita. 2007. "Antiradical Activity of Paulownia tomentosa (Scrophulariaceae) Extracts." Molecules 12, no. 6: 1210-1219.