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Cancer Preventive Mechanismsof the Green Tea Polyphenol (-)-Epigallocatechin-3-gallate
College of Life Sciences, Shandong Normal University, Jinan 250014, P. R. China
Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Center for Advanced Study, Shandong University of Technology, Zibo 255049, P. R. China
* Author to whom correspondence should be addressed.
Received: 15 March 2007; in revised form: 30 April 2007 / Accepted: 1 May 2007 / Published: 3 May 2007
Abstract: Accumulating evidence indicates that consumption of tea, especially green tea, is good for preventing cancer. To elucidate the cancer preventive mechanisms of green tea, much effort has been devoted to investigating the anticancer effects of (-)-epigallocatechin-3-gallate (EGCG), the major component of green tea. It has been revealed that EGCG restrained carcinogenesis in a variety of tissues through inhibition of mitogen-activated protein kinases (MAPK), growth factor-related cell signaling, activation of activator protein 1 (AP-1) and nuclear factor-B (NF-κB), topoisomerase I, matrix metalloproteinases and other potential targets. Therefore, EGCG is a multipotent anticancer agent, which not only provides solid evidence to support the anticancer potential of green tea, but also offers new clues for discovering multiple-targeted anticancer drugs.
Keywords: Green tea; (-)-Epigallocatechin gallate; Cancer prevention; Mechanisms
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MDPI and ACS Style
Chen, L.; Zhang, H.-Y. Cancer Preventive Mechanismsof the Green Tea Polyphenol (-)-Epigallocatechin-3-gallate. Molecules 2007, 12, 946-957.
Chen L, Zhang H-Y. Cancer Preventive Mechanismsof the Green Tea Polyphenol (-)-Epigallocatechin-3-gallate. Molecules. 2007; 12(5):946-957.
Chen, Lei; Zhang, Hong-Yu. 2007. "Cancer Preventive Mechanismsof the Green Tea Polyphenol (-)-Epigallocatechin-3-gallate." Molecules 12, no. 5: 946-957.