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Molecularly Imprinted Polymers for 5-Fluorouracil Release in Biological Fluids
Dipartimento di Scienze Farmaceutiche, Università della Calabria, Edificio Polifunzionale, Arcavacata di Rende (CS) 87036, Italy
Dipartimento di Studi di Chimica e Tecnologia delle Sostanze Biologicamente Attive, University “La Sapienza”, P.le A. Moro 5, 00185 Roma, Italy
* Author to whom correspondence should be addressed.
Received: 21 March 2007; in revised form: 13 March 2007 / Accepted: 16 April 2007 / Published: 18 April 2007
Abstract: The aim of this work was to investigate the possibility of employing Molecularly Imprinted Polymers (MIPs) as a controlled release device for 5-fluorouracil (5-FU) in biological fluids, especially gastrointestinal ones, compared to Non Imprinted Polymers (NIPs). MIPs were synthesized using methacrylic acid (MAA) as functional monomer and ethylene glycol dimethacrylate (EGDMA) as crosslinking agent. The capacity of the polymer to recognize and to bind the template selectively in both organic and aqueous media was evaluated. An in vitro release study was performed both in gastrointestinal and in plasma simulating fluids. The imprinted polymers bound much more 5-Fu than the corresponding non-imprinted ones and showed a controlled/sustained drug release, with MIPs release rate being indeed much more sustained than that obtained from NIPs. These polymers represent a potential valid system for drug delivery and this study indicates that the selective binding characteristic of molecularly imprinted polymers is promising for the preparation of novel controlled release drug dosage form.
Keywords: 5-Fluorouracil; Drug Delivery System; Molecular Imprinting; Radical Polymerization; Sustained Release
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MDPI and ACS Style
Puoci, F.; Iemma, F.; Cirillo, G.; Picci, N.; Matricardi, P.; Alhaique, F. Molecularly Imprinted Polymers for 5-Fluorouracil Release in Biological Fluids. Molecules 2007, 12, 805-814.
Puoci F, Iemma F, Cirillo G, Picci N, Matricardi P, Alhaique F. Molecularly Imprinted Polymers for 5-Fluorouracil Release in Biological Fluids. Molecules. 2007; 12(4):805-814.
Puoci, Francesco; Iemma, Francesca; Cirillo, Giuseppe; Picci, Nevio; Matricardi, Pietro; Alhaique, Franco. 2007. "Molecularly Imprinted Polymers for 5-Fluorouracil Release in Biological Fluids." Molecules 12, no. 4: 805-814.