Next Article in Journal
Molecularly Imprinted Polymers for 5-Fluorouracil Release in Biological Fluids
Previous Article in Journal
Complexes of 3dn Metal Ions with Thiosemicarbazones: Synthesis and Antimicrobial Activity
Article Menu

Export Article

Open AccessArticle
Molecules 2007, 12(4), 797-804; doi:10.3390/12040797

Synthesis of α,β-Unsaturated Ketones as Chalcone Analogues via a SRN1 Mechanism

Laboratoire de Chimie Organique Pharmaceutique, UMR CNRS 6517, Université de la Méditerranée, Faculté de Pharmacie, 27, boulevard Jean Moulin, 13385 Marseille Cedex 05, France
*
Author to whom correspondence should be addressed.
Received: 13 February 2007 / Revised: 14 April 2007 / Accepted: 16 April 2007 / Published: 18 April 2007
View Full-Text   |   Download PDF [66 KB, uploaded 18 June 2014]   |  

Abstract

An electron-transfer chain reaction between 2-nitropropane anion and α-bromoketones derived from nitrobenzene and nitrothiophene was demonstrated by mechanistic study and a specific convenient synthetic protocol. Thus, 2-bromo-1-(5-nitrothiophen-2-yl)ethanone or 2-bromo-1-(4-nitrophenyl)ethanone were reacted with several cyclic nitronate anions to form α,β-unsaturated ketones via a SRN1 mechanism. This new method can be used to synthesize a wide variety of chalcone analogues. View Full-Text
Keywords: SRN1; nitrothiophene; nitrophenylethanone; a; b-unsaturated ketones; chalcones SRN1; nitrothiophene; nitrophenylethanone; a; b-unsaturated ketones; chalcones
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Curti, C.; Gellis, A.; Vanelle, P. Synthesis of α,β-Unsaturated Ketones as Chalcone Analogues via a SRN1 Mechanism. Molecules 2007, 12, 797-804.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top