Molecules 2007, 12(4), 815-820; doi:10.3390/12040815
Communication

Bis(4-hydroxybenzyl)sulfide: a Sulfur Compound Inhibitor of Histone Deacetylase Isolated from Root Extract of Pleuropterus ciliinervis

Il Hong Son, Sung Ik Lee, Hyun Duk Yang and Hyung-In Moon* email
Department of Neuroscience and Inam Neuro Science Research Center, Sanbon Medical Center, Wonkwang University, Gunpo-city, Kyunggido, 435-040, South Korea
* Author to whom correspondence should be addressed.
Received: 5 April 2007; in revised form: 16 April 2007 / Accepted: 16 April 2007 / Published: 20 April 2007
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Abstract: A sulfur compound, bis(4-hydroxybenzyl)sulfide (1) was isolated from the root extract of Pleuropterus ciliinervis. Its structure was elucidated using NMR spectroscopic techniques and mass spectrometric analysis. Compound 1 showed potent inhibitory activity in a histone deacetylase (HDAC) enzyme assay. It also exhibited growth inhibitory activity on five human tumor cell lines and more sensitive inhibitory activity on the MDA-MB-231 breast tumor cell line.
Keywords: Sulfur compound; HDAC; Pleuropterus ciliinervis; tumor cell lines

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Cite This Article

MDPI and ACS Style

Son, I.H.; Lee, S.I.; Yang, H.D.; Moon, H.-I. Bis(4-hydroxybenzyl)sulfide: a Sulfur Compound Inhibitor of Histone Deacetylase Isolated from Root Extract of Pleuropterus ciliinervis. Molecules 2007, 12, 815-820.

AMA Style

Son IH, Lee SI, Yang HD, Moon H-I. Bis(4-hydroxybenzyl)sulfide: a Sulfur Compound Inhibitor of Histone Deacetylase Isolated from Root Extract of Pleuropterus ciliinervis. Molecules. 2007; 12(4):815-820.

Chicago/Turabian Style

Son, Il H.; Lee, Sung I.; Yang, Hyun D.; Moon, Hyung-In. 2007. "Bis(4-hydroxybenzyl)sulfide: a Sulfur Compound Inhibitor of Histone Deacetylase Isolated from Root Extract of Pleuropterus ciliinervis." Molecules 12, no. 4: 815-820.

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