Molecules 2007, 12(4), 815-820; doi:10.3390/12040815
Communication

Bis(4-hydroxybenzyl)sulfide: a Sulfur Compound Inhibitor of Histone Deacetylase Isolated from Root Extract of Pleuropterus ciliinervis

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Received: 5 April 2007; in revised form: 16 April 2007 / Accepted: 16 April 2007 / Published: 20 April 2007
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: A sulfur compound, bis(4-hydroxybenzyl)sulfide (1) was isolated from the root extract of Pleuropterus ciliinervis. Its structure was elucidated using NMR spectroscopic techniques and mass spectrometric analysis. Compound 1 showed potent inhibitory activity in a histone deacetylase (HDAC) enzyme assay. It also exhibited growth inhibitory activity on five human tumor cell lines and more sensitive inhibitory activity on the MDA-MB-231 breast tumor cell line.
Keywords: Sulfur compound; HDAC; Pleuropterus ciliinervis; tumor cell lines
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MDPI and ACS Style

Son, I.H.; Lee, S.I.; Yang, H.D.; Moon, H.-I. Bis(4-hydroxybenzyl)sulfide: a Sulfur Compound Inhibitor of Histone Deacetylase Isolated from Root Extract of Pleuropterus ciliinervis. Molecules 2007, 12, 815-820.

AMA Style

Son IH, Lee SI, Yang HD, Moon H-I. Bis(4-hydroxybenzyl)sulfide: a Sulfur Compound Inhibitor of Histone Deacetylase Isolated from Root Extract of Pleuropterus ciliinervis. Molecules. 2007; 12(4):815-820.

Chicago/Turabian Style

Son, Il H.; Lee, Sung I.; Yang, Hyun D.; Moon, Hyung-In. 2007. "Bis(4-hydroxybenzyl)sulfide: a Sulfur Compound Inhibitor of Histone Deacetylase Isolated from Root Extract of Pleuropterus ciliinervis." Molecules 12, no. 4: 815-820.


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