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Molecules 2007, 12(4), 815-820; doi:10.3390/12040815
Communication

Bis(4-hydroxybenzyl)sulfide: a Sulfur Compound Inhibitor of Histone Deacetylase Isolated from Root Extract of Pleuropterus ciliinervis

, ,  and *
Department of Neuroscience and Inam Neuro Science Research Center, Sanbon Medical Center, Wonkwang University, Gunpo-city, Kyunggido, 435-040, South Korea
* Author to whom correspondence should be addressed.
Received: 5 April 2007 / Revised: 16 April 2007 / Accepted: 16 April 2007 / Published: 20 April 2007
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Abstract

A sulfur compound, bis(4-hydroxybenzyl)sulfide (1) was isolated from the root extract of Pleuropterus ciliinervis. Its structure was elucidated using NMR spectroscopic techniques and mass spectrometric analysis. Compound 1 showed potent inhibitory activity in a histone deacetylase (HDAC) enzyme assay. It also exhibited growth inhibitory activity on five human tumor cell lines and more sensitive inhibitory activity on the MDA-MB-231 breast tumor cell line.
Keywords: Sulfur compound; HDAC; Pleuropterus ciliinervis; tumor cell lines Sulfur compound; HDAC; Pleuropterus ciliinervis; tumor cell lines
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Son, I.H.; Lee, S.I.; Yang, H.D.; Moon, H.-I. Bis(4-hydroxybenzyl)sulfide: a Sulfur Compound Inhibitor of Histone Deacetylase Isolated from Root Extract of Pleuropterus ciliinervis. Molecules 2007, 12, 815-820.

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