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Complexes of 3dn Metal Ions with Thiosemicarbazones: Synthesis and Antimicrobial Activity
Inorganic Chemistry Department, University of Bucharest, 23 Dumbrava Rosie Street, sector 2, Bucharest, Romania
Faculty of Chemistry, Inorganic Chemistry Department, USM-R, Moldova
Organic Chemistry Department, University of Bucharest, 90 – 92 Panduri Bd., sector 4, Bucharest, Romania
Nuclear Physics and Engineering Institute “Horia Hulubei”, Bucharest, Romania
* Author to whom correspondence should be addressed.
Received: 27 February 2007; in revised form: 5 April 2007 / Accepted: 12 April 2007 / Published: 17 April 2007
Abstract: The chelating behavior of the thiosemicarbazone derivatives of 2-hydroxy-8-R-tricyclo[18.104.22.168.2,7]tridecane-13-one (where R = H, CH3, C6H5) towards Co(II), Ni(II) and Cu(II) has been investigated by elemental analysis, molar conductivity measurements, UV-VIS, IR, ESR spectroscopy and thermal studies. It was deduced from the experiments performed that the ligands coordinate to metal ions in different ways – neutral bidentate or mononegative bidentate – depending on the nature of R. Also, if metal acetates are used instead of metal chlorides, the ligands coordinate in a mononegative bidentate fashion, regardless of the nature of R or the thiosemicarbazone type ligand. The antimicrobial activity of the ligands and of the complexes towards samples of Acinetobacter boumanii, Klebsiella pneumoniae, Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa was determined.
Keywords: Thiosemicarbazone complexes; copper complexes; thiosemicarbazones; antimicrobial activity
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Rosu, T.; Gulea, A.; Nicolae, A.; Georgescu, R. Complexes of 3dn Metal Ions with Thiosemicarbazones: Synthesis and Antimicrobial Activity. Molecules 2007, 12, 782-796.
Rosu T, Gulea A, Nicolae A, Georgescu R. Complexes of 3dn Metal Ions with Thiosemicarbazones: Synthesis and Antimicrobial Activity. Molecules. 2007; 12(4):782-796.
Rosu, Tudor; Gulea, Aurelian; Nicolae, Anca; Georgescu, Rodica. 2007. "Complexes of 3dn Metal Ions with Thiosemicarbazones: Synthesis and Antimicrobial Activity." Molecules 12, no. 4: 782-796.