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Complexes of 3dn Metal Ions with Thiosemicarbazones: Synthesis and Antimicrobial Activity
AbstractThe chelating behavior of the thiosemicarbazone derivatives of 2-hydroxy-8-R-tricyclo[188.8.131.52.2,7]tridecane-13-one (where R = H, CH3, C6H5) towards Co(II), Ni(II) and Cu(II) has been investigated by elemental analysis, molar conductivity measurements, UV-VIS, IR, ESR spectroscopy and thermal studies. It was deduced from the experiments performed that the ligands coordinate to metal ions in different ways – neutral bidentate or mononegative bidentate – depending on the nature of R. Also, if metal acetates are used instead of metal chlorides, the ligands coordinate in a mononegative bidentate fashion, regardless of the nature of R or the thiosemicarbazone type ligand. The antimicrobial activity of the ligands and of the complexes towards samples of Acinetobacter boumanii, Klebsiella pneumoniae, Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa was determined.
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Rosu, T.; Gulea, A.; Nicolae, A.; Georgescu, R. Complexes of 3dn Metal Ions with Thiosemicarbazones: Synthesis and Antimicrobial Activity. Molecules 2007, 12, 782-796.View more citation formats
Rosu T, Gulea A, Nicolae A, Georgescu R. Complexes of 3dn Metal Ions with Thiosemicarbazones: Synthesis and Antimicrobial Activity. Molecules. 2007; 12(4):782-796.Chicago/Turabian Style
Rosu, Tudor; Gulea, Aurelian; Nicolae, Anca; Georgescu, Rodica. 2007. "Complexes of 3dn Metal Ions with Thiosemicarbazones: Synthesis and Antimicrobial Activity." Molecules 12, no. 4: 782-796.
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