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• Gulea, A
• Nicolae, A
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• Nicolae, A
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• Gulea, A
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Molecules 2007, 12(4), 782-796; doi:10.3390/12040782

Article

Complexes of 3dⁿ Metal Ions with Thiosemicarbazones: Synthesis and Antimicrobial Activity

Tudor Rosu ^1,* , Aurelian Gulea ², Anca Nicolae ³ and Rodica Georgescu ⁴

¹ Inorganic Chemistry Department, University of Bucharest, 23 Dumbrava Rosie Street, sector 2, Bucharest, Romania ² Faculty of Chemistry, Inorganic Chemistry Department, USM-R, Moldova ³ Organic Chemistry Department, University of Bucharest, 90 – 92 Panduri Bd., sector 4, Bucharest, Romania ⁴ Nuclear Physics and Engineering Institute “Horia Hulubei”, Bucharest, Romania

* Author to whom correspondence should be addressed.

Received: 27 February 2007; in revised form: 5 April 2007 / Accepted: 12 April 2007 / Published: 17 April 2007

Download PDF Full-Text [204 KB, uploaded 2 October 2008 11:53 CEST]

Abstract: The chelating behavior of the thiosemicarbazone derivatives of 2-hydroxy-8-R-tricyclo[7.3.1.0.^2,7]tridecane-13-one (where R = H, CH₃, C₆H₅) towards Co(II), Ni(II) and Cu(II) has been investigated by elemental analysis, molar conductivity measurements, UV-VIS, IR, ESR spectroscopy and thermal studies. It was deduced from the experiments performed that the ligands coordinate to metal ions in different ways – neutral bidentate or mononegative bidentate – depending on the nature of R. Also, if metal acetates are used instead of metal chlorides, the ligands coordinate in a mononegative bidentate fashion, regardless of the nature of R or the thiosemicarbazone type ligand. The antimicrobial activity of the ligands and of the complexes towards samples of Acinetobacter boumanii, Klebsiella pneumoniae, Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa was determined.

Keywords: Thiosemicarbazone complexes; copper complexes; thiosemicarbazones; antimicrobial activity

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