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Molecules 2007, 12(3), 582-592; doi:10.3390/12030582
Article

Proteasome and NF-κB Inhibiting Phaeophytins from the Green Alga Cladophora fascicularis

1, 1
,
1, 2, 3 and 1,*
1 State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, P.R. China 2 Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, P.R. China 3 Analytic and Testing Center, Beijing Normal University, Beijing 100073, P.R. China
* Author to whom correspondence should be addressed.
Received: 18 February 2007 / Revised: 18 March 2007 / Accepted: 21 March 2007 / Published: 21 March 2007
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Abstract

Chemical examination of the green alga Cladophora fascicularis resulted in the isolation and characterization of a new porphyrin derivative, porphyrinolactone (1), along with five known phaeophytins 2-6 and fourteen sterols and cycloartanes. The structure of 1 was determined on the basis of spectroscopic analyses and by comparison of its NMR data with those of known phaeophytins. Compounds 1-6 displayed moderate inhibition of tumor necrosis factor alpha (TNF-α) induced nuclear factor-κB (NF-κB) activation, while 2 and 4 displayed potential inhibitory activity toward proteasome chymotripsin-like activation. The primary structure-activity relationship was also discussed.
Keywords: Green alga; Cladophora fascicularis; porphyrinolactone; NF-kB; proteasome Green alga; Cladophora fascicularis; porphyrinolactone; NF-kB; proteasome
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Huang, X.; Li, M.; Xu, B.; Zhu, X.; Deng, Z.; Lin, W. Proteasome and NF-κB Inhibiting Phaeophytins from the Green Alga Cladophora fascicularis. Molecules 2007, 12, 582-592.

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