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Proteasome and NF-κB Inhibiting Phaeophytins from the Green Alga Cladophora fascicularis
State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, P.R. China
Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, P.R. China
Analytic and Testing Center, Beijing Normal University, Beijing 100073, P.R. China
* Author to whom correspondence should be addressed.
Received: 18 February 2007; in revised form: 18 March 2007 / Accepted: 21 March 2007 / Published: 21 March 2007
Abstract: Chemical examination of the green alga Cladophora fascicularis resulted in the isolation and characterization of a new porphyrin derivative, porphyrinolactone (1), along with five known phaeophytins 2-6 and fourteen sterols and cycloartanes. The structure of 1 was determined on the basis of spectroscopic analyses and by comparison of its NMR data with those of known phaeophytins. Compounds 1-6 displayed moderate inhibition of tumor necrosis factor alpha (TNF-α) induced nuclear factor-κB (NF-κB) activation, while 2 and 4 displayed potential inhibitory activity toward proteasome chymotripsin-like activation. The primary structure-activity relationship was also discussed.
Keywords: Green alga; Cladophora fascicularis; porphyrinolactone; NF-kB; proteasome
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MDPI and ACS Style
Huang, X.; Li, M.; Xu, B.; Zhu, X.; Deng, Z.; Lin, W. Proteasome and NF-κB Inhibiting Phaeophytins from the Green Alga Cladophora fascicularis. Molecules 2007, 12, 582-592.
Huang X, Li M, Xu B, Zhu X, Deng Z, Lin W. Proteasome and NF-κB Inhibiting Phaeophytins from the Green Alga Cladophora fascicularis. Molecules. 2007; 12(3):582-592.
Huang, Xinping; Li, Min; Xu, Bo; Zhu, Xiaobin; Deng, Zhiwei; Lin, Wenhan. 2007. "Proteasome and NF-κB Inhibiting Phaeophytins from the Green Alga Cladophora fascicularis." Molecules 12, no. 3: 582-592.