Next Article in Journal
Characterization of Flavonoid Subgroups and Hydroxy Substitution by HPLC-MS/MS
Previous Article in Journal
Phenolic Content and Antioxidant Properties of Soybean (Glycine max (L.) Merr.) Seeds
Article Menu

Export Article

Open AccessArticle
Molecules 2007, 12(3), 582-592; doi:10.3390/12030582

Proteasome and NF-κB Inhibiting Phaeophytins from the Green Alga Cladophora fascicularis

State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, P.R. China
Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, P.R. China
Analytic and Testing Center, Beijing Normal University, Beijing 100073, P.R. China
Author to whom correspondence should be addressed.
Received: 18 February 2007 / Revised: 18 March 2007 / Accepted: 21 March 2007 / Published: 21 March 2007
View Full-Text   |   Download PDF [202 KB, uploaded 18 June 2014]   |  


Chemical examination of the green alga Cladophora fascicularis resulted in the isolation and characterization of a new porphyrin derivative, porphyrinolactone (1), along with five known phaeophytins 2-6 and fourteen sterols and cycloartanes. The structure of 1 was determined on the basis of spectroscopic analyses and by comparison of its NMR data with those of known phaeophytins. Compounds 1-6 displayed moderate inhibition of tumor necrosis factor alpha (TNF-α) induced nuclear factor-κB (NF-κB) activation, while 2 and 4 displayed potential inhibitory activity toward proteasome chymotripsin-like activation. The primary structure-activity relationship was also discussed.
Keywords: Green alga; Cladophora fascicularis; porphyrinolactone; NF-kB; proteasome Green alga; Cladophora fascicularis; porphyrinolactone; NF-kB; proteasome
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Huang, X.; Li, M.; Xu, B.; Zhu, X.; Deng, Z.; Lin, W. Proteasome and NF-κB Inhibiting Phaeophytins from the Green Alga Cladophora fascicularis. Molecules 2007, 12, 582-592.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top