Abstract: Chemical examination of the green alga Cladophora fascicularis resulted in the isolation and characterization of a new porphyrin derivative, porphyrinolactone (1), along with five known phaeophytins 2-6 and fourteen sterols and cycloartanes. The structure of 1 was determined on the basis of spectroscopic analyses and by comparison of its NMR data with those of known phaeophytins. Compounds 1-6 displayed moderate inhibition of tumor necrosis factor alpha (TNF-α) induced nuclear factor-κB (NF-κB) activation, while 2 and 4 displayed potential inhibitory activity toward proteasome chymotripsin-like activation. The primary structure-activity relationship was also discussed.
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Huang, X.; Li, M.; Xu, B.; Zhu, X.; Deng, Z.; Lin, W. Proteasome and NF-κB Inhibiting Phaeophytins from the Green Alga Cladophora fascicularis. Molecules 2007, 12, 582-592.
Huang X, Li M, Xu B, Zhu X, Deng Z, Lin W. Proteasome and NF-κB Inhibiting Phaeophytins from the Green Alga Cladophora fascicularis. Molecules. 2007; 12(3):582-592.
Huang, Xinping; Li, Min; Xu, Bo; Zhu, Xiaobin; Deng, Zhiwei; Lin, Wenhan. 2007. "Proteasome and NF-κB Inhibiting Phaeophytins from the Green Alga Cladophora fascicularis." Molecules 12, no. 3: 582-592.