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Molecules 2007, 12(3), 582-592; doi:10.3390/12030582
Article

Proteasome and NF-κB Inhibiting Phaeophytins from the Green Alga Cladophora fascicularis

1, 1
, 1, 2, 3 and 1,*
Received: 18 February 2007; in revised form: 18 March 2007 / Accepted: 21 March 2007 / Published: 21 March 2007
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Abstract: Chemical examination of the green alga Cladophora fascicularis resulted in the isolation and characterization of a new porphyrin derivative, porphyrinolactone (1), along with five known phaeophytins 2-6 and fourteen sterols and cycloartanes. The structure of 1 was determined on the basis of spectroscopic analyses and by comparison of its NMR data with those of known phaeophytins. Compounds 1-6 displayed moderate inhibition of tumor necrosis factor alpha (TNF-α) induced nuclear factor-κB (NF-κB) activation, while 2 and 4 displayed potential inhibitory activity toward proteasome chymotripsin-like activation. The primary structure-activity relationship was also discussed.
Keywords: Green alga; Cladophora fascicularis; porphyrinolactone; NF-kB; proteasome Green alga; Cladophora fascicularis; porphyrinolactone; NF-kB; proteasome
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Huang, X.; Li, M.; Xu, B.; Zhu, X.; Deng, Z.; Lin, W. Proteasome and NF-κB Inhibiting Phaeophytins from the Green Alga Cladophora fascicularis. Molecules 2007, 12, 582-592.

AMA Style

Huang X, Li M, Xu B, Zhu X, Deng Z, Lin W. Proteasome and NF-κB Inhibiting Phaeophytins from the Green Alga Cladophora fascicularis. Molecules. 2007; 12(3):582-592.

Chicago/Turabian Style

Huang, Xinping; Li, Min; Xu, Bo; Zhu, Xiaobin; Deng, Zhiwei; Lin, Wenhan. 2007. "Proteasome and NF-κB Inhibiting Phaeophytins from the Green Alga Cladophora fascicularis." Molecules 12, no. 3: 582-592.



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