Microwave-promoted Facile and Efficient Preparation of N-(alkoxycarbonylmethyl) Nucleobases − Building Blocks for Peptide Nucleic Acids

doi:10.3390/12030543

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Molecules 2007, 12(3), 543-551; doi:10.3390/12030543

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Microwave-promoted Facile and Efficient Preparation of N-(alkoxycarbonylmethyl) Nucleobases − Building Blocks for Peptide Nucleic Acids

Guirong Qu* , Zhiguang Zhang, Haiming Guo, Mingwei Geng and Ran Xia

College of Chemistry and Environmental Science, Henan Normal University, Xinxiang 453007, P.R. China

* Author to whom correspondence should be addressed.

Received: 13 December 2006; in revised form: 11 February 2007 / Accepted: 17 February 2007 / Published: 19 March 2007

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Abstract: A simple, rapid, and regioselective approach for the synthesis of N-(methoxy-carbonylmethyl)- and N-(n-propoxycarbonylmethyl) nucleobases was developed. By using DMF as the solvent and in the presence of K₂CO₃ as the base, all the desired products were obtained in moderate yields within 8 min under microwave irradiation.

Keywords: Modified nucleoside analogues; microwave irradiation; peptide nucleic acids

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MDPI and ACS Style

Qu, G.; Zhang, Z.; Guo, H.; Geng, M.; Xia, R. Microwave-promoted Facile and Efficient Preparation of N-(alkoxycarbonylmethyl) Nucleobases − Building Blocks for Peptide Nucleic Acids. Molecules 2007, 12, 543-551.

AMA Style

Qu G., Zhang Z., Guo H., Geng M., Xia R. Microwave-promoted Facile and Efficient Preparation of N-(alkoxycarbonylmethyl) Nucleobases − Building Blocks for Peptide Nucleic Acids. Molecules. 2007; 12(3):543-551.

Chicago/Turabian Style

Qu, Guirong; Zhang, Zhiguang; Guo, Haiming; Geng, Mingwei; Xia, Ran. 2007. "Microwave-promoted Facile and Efficient Preparation of N-(alkoxycarbonylmethyl) Nucleobases − Building Blocks for Peptide Nucleic Acids." Molecules 12, no. 3: 543-551.

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