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Molecules 2007, 12(3), 543-551; doi:10.3390/12030543
Article

Microwave-promoted Facile and Efficient Preparation of N-(alkoxycarbonylmethyl) Nucleobases − Building Blocks for Peptide Nucleic Acids

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College of Chemistry and Environmental Science, Henan Normal University, Xinxiang 453007, P.R. China
* Author to whom correspondence should be addressed.
Received: 13 December 2006 / Revised: 11 February 2007 / Accepted: 17 February 2007 / Published: 19 March 2007
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Abstract

A simple, rapid, and regioselective approach for the synthesis of N-(methoxy-carbonylmethyl)- and N-(n-propoxycarbonylmethyl) nucleobases was developed. By using DMF as the solvent and in the presence of K2CO3 as the base, all the desired products were obtained in moderate yields within 8 min under microwave irradiation.
Keywords: Modified nucleoside analogues; microwave irradiation; peptide nucleic acids Modified nucleoside analogues; microwave irradiation; peptide nucleic acids
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Qu, G.; Zhang, Z.; Guo, H.; Geng, M.; Xia, R. Microwave-promoted Facile and Efficient Preparation of N-(alkoxycarbonylmethyl) Nucleobases − Building Blocks for Peptide Nucleic Acids. Molecules 2007, 12, 543-551.

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