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Molecules 2007, 12(3), 536-542; doi:10.3390/12030536

New Cytotoxic Steroid from Stachyurus imalaicus var. himalaicus

1,* , 2, 1
1 Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, P.R. China 2 Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, P.R. China
* Author to whom correspondence should be addressed.
Received: 20 December 2006 / Revised: 11 February 2007 / Accepted: 17 February 2007 / Published: 17 March 2007
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A phytochemical study of the ethanolic extract of Stachyurus imalaicus var. himalaicus was undertaken and as a result a new polyoxygenated steroid, named stachsterol ((20S)-20, 25-dihydroxy-4-cholesten-3-one, 1) and three known ecdysteroids, 20-hydroxyecdysone (2), 20-hydroxyecdysone-20, 22-monoacetonide (3) and polypodine B-20,22-monoacetonide (4), were isolated. Their structures were elucidated by spectroscopic methods, including UV, NMR, MS and HR-MS. The purified product 1 was found to have in vitro cytotoxic activity against human Hela cell lines with an IC50 value of 2.5 μg/mL. This is the first time that phytoecdysteroids have been found in the genus Stachyurus.
Keywords: Steroids; Stachyurus himalaicus var. himalaicus; Stachyuraceae; Cytotoxity Steroids; Stachyurus himalaicus var. himalaicus; Stachyuraceae; Cytotoxity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Wang, Y.-S.; Yang, J.-H.; Luo, S.-D.; Zhang, H.-B.; Li, L. New Cytotoxic Steroid from Stachyurus imalaicus var. himalaicus. Molecules 2007, 12, 536-542.

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