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Molecules 2007, 12(3), 536-542; doi:10.3390/12030536
Communication

New Cytotoxic Steroid from Stachyurus imalaicus var. himalaicus

1
, 1,* , 2, 1
 and 1
Received: 20 December 2006 / Revised: 11 February 2007 / Accepted: 17 February 2007 / Published: 17 March 2007
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Abstract: A phytochemical study of the ethanolic extract of Stachyurus imalaicus var. himalaicus was undertaken and as a result a new polyoxygenated steroid, named stachsterol ((20S)-20, 25-dihydroxy-4-cholesten-3-one, 1) and three known ecdysteroids, 20-hydroxyecdysone (2), 20-hydroxyecdysone-20, 22-monoacetonide (3) and polypodine B-20,22-monoacetonide (4), were isolated. Their structures were elucidated by spectroscopic methods, including UV, NMR, MS and HR-MS. The purified product 1 was found to have in vitro cytotoxic activity against human Hela cell lines with an IC50 value of 2.5 μg/mL. This is the first time that phytoecdysteroids have been found in the genus Stachyurus.
Keywords: Steroids; Stachyurus himalaicus var. himalaicus; Stachyuraceae; Cytotoxity Steroids; Stachyurus himalaicus var. himalaicus; Stachyuraceae; Cytotoxity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Wang, Y.-S.; Yang, J.-H.; Luo, S.-D.; Zhang, H.-B.; Li, L. New Cytotoxic Steroid from Stachyurus imalaicus var. himalaicus. Molecules 2007, 12, 536-542.

AMA Style

Wang Y-S, Yang J-H, Luo S-D, Zhang H-B, Li L. New Cytotoxic Steroid from Stachyurus imalaicus var. himalaicus. Molecules. 2007; 12(3):536-542.

Chicago/Turabian Style

Wang, Yun-Song; Yang, Jing-Hua; Luo, Shi-De; Zhang, Hong-Bin; Li, Liang. 2007. "New Cytotoxic Steroid from Stachyurus imalaicus var. himalaicus." Molecules 12, no. 3: 536-542.


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