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Reactive Oxygen Species Scavenging Activity of Flavone Glycosides from Melilotus neapolitana
Dipartimento di Scienze della Vita, Seconda Università degli Studi di Napoli – via Vivaldi 43, I-81100 Caserta, Italy
* Author to whom correspondence should be addressed.
Received: 21 January 2007; in revised form: 13 February 2007 / Accepted: 27 February 2007 / Published: 28 February 2007
Abstract: One new and six known flavone glycosides were isolated from the MeOH extract of Melilotus neapolitana Ten. The new compound, identified as 7-O-β-D-gluco-pyranosyloxy-4',5-dihydroxy-3-[O-α-L-rhamnopyranosyl-(1→6)-3-O-β-D-glucopyrano-syloxy]flavone (1) by 1D and 2D NMR techniques and mass spectra, was isolated along with kaempferol-3-O-rutinoside (2), kaempferol-3-O-glucoside (3), rutin (4), quercetin-3-O-glucoside (5), isorhamnetin-3-O-rutinoside (6), and isorhamnetin-3-O-glucoside (7). The antioxidant and radical scavenging activities of these compounds and the whole crude methanol extract were evaluated. The organic extract can inhibit MDA marker’s synthesis by 57%. All the metabolites displayed good reducing power, with the kaempferol (2,3) and isorhamnetin derivatives (6,7) being less active than the corresponding quercetin derivatives 4,5.
Keywords: Melilotus neapolitana Ten; flavone glycosides; ROSs; antioxidant activity
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Fiorentino, A.; D'Abrosca, B.; Pacifico, S.; Golino, A.; Mastellone, C.; Oriano, P.; Monaco, P. Reactive Oxygen Species Scavenging Activity of Flavone Glycosides from Melilotus neapolitana. Molecules 2007, 12, 263-270.
Fiorentino A, D'Abrosca B, Pacifico S, Golino A, Mastellone C, Oriano P, Monaco P. Reactive Oxygen Species Scavenging Activity of Flavone Glycosides from Melilotus neapolitana. Molecules. 2007; 12(2):263-270.
Fiorentino, Antonio; D'Abrosca, Brigida; Pacifico, Severina; Golino, Annunziata; Mastellone, Claudio; Oriano, Palma; Monaco, Pietro. 2007. "Reactive Oxygen Species Scavenging Activity of Flavone Glycosides from Melilotus neapolitana." Molecules 12, no. 2: 263-270.