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Molecules 2007, 12(2), 263-270; doi:10.3390/12020263
Article

Reactive Oxygen Species Scavenging Activity of Flavone Glycosides from Melilotus neapolitana

, , , , ,  and
Dipartimento di Scienze della Vita, Seconda Università degli Studi di Napoli – via Vivaldi 43, I-81100 Caserta, Italy
* Author to whom correspondence should be addressed.
Received: 21 January 2007 / Revised: 13 February 2007 / Accepted: 27 February 2007 / Published: 28 February 2007
(This article belongs to the Special Issue Phenolics and Polyphenolics)
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Abstract

One new and six known flavone glycosides were isolated from the MeOH extract of Melilotus neapolitana Ten. The new compound, identified as 7-O-β-D-gluco-pyranosyloxy-4',5-dihydroxy-3-[O-α-L-rhamnopyranosyl-(1→6)-3-O-β-D-glucopyrano-syloxy]flavone (1) by 1D and 2D NMR techniques and mass spectra, was isolated along with kaempferol-3-O-rutinoside (2), kaempferol-3-O-glucoside (3), rutin (4), quercetin-3-O-glucoside (5), isorhamnetin-3-O-rutinoside (6), and isorhamnetin-3-O-glucoside (7). The antioxidant and radical scavenging activities of these compounds and the whole crude methanol extract were evaluated. The organic extract can inhibit MDA marker’s synthesis by 57%. All the metabolites displayed good reducing power, with the kaempferol (2,3) and isorhamnetin derivatives (6,7) being less active than the corresponding quercetin derivatives 4,5.
Keywords: Melilotus neapolitana Ten; flavone glycosides; ROSs; antioxidant activity Melilotus neapolitana Ten; flavone glycosides; ROSs; antioxidant activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fiorentino, A.; D'Abrosca, B.; Pacifico, S.; Golino, A.; Mastellone, C.; Oriano, P.; Monaco, P. Reactive Oxygen Species Scavenging Activity of Flavone Glycosides from Melilotus neapolitana. Molecules 2007, 12, 263-270.

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