Molecules 2007, 12(2), 271-282; doi:10.3390/12020271
Article

Synthesis and Biological Evaluation of Rigid Polycyclic Derivatives of the Diels-Alder Adduct Tricyclo[6.2.1.02,7]undeca-4,9-dien-3,6-dione

Felicia Megumi Ito1 email, Jacqueline Marques Petroni1 email, Dênis Pires De Lima1 email, Adilson Beatriz1,* email, Maria Rita Marques2 email, Manoel Odorico De Moraes3 email, Letícia Veras Costa-Lotufo3 email, Raquel Carvalho Montenegro3 , Hemerson Iury Ferreira Magalhãe3 email and Cláudia Do Ó Pessoa3 email
1 Department of Chemistry, Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil 2 Department of Morphophysiology, Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil 3 Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil
* Author to whom correspondence should be addressed.
Received: 30 January 2007; in revised form: 14 February 2007 / Accepted: 16 February 2007 / Published: 27 February 2007
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Abstract: art of our research program concentrates on the discovery of new bioactivecompounds prepared either by total synthesis or molecular transformation of compoundswith bioactivity profiles. In this work we have focused our interest on chemicaltransformations of the Diels-Alder adduct tricyclo[6.2.1.02,7]undeca-4,9-dien-3,6-dione inorder to obtain cage-like compounds and derivatives, followed by an evaluation of theirbiological activity.
Keywords: Tricyclo[6.2.1.02; 7]undecane ring system;cage-like compounds;Diels-Alder adducts;biological activity.

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MDPI and ACS Style

Ito, F.M.; Petroni, J.M.; De Lima, D.P.; Beatriz, A.; Marques, M.R.; De Moraes, M.O.; Costa-Lotufo, L.V.; Montenegro, R.C.; Ferreira Magalhãe, H.I.; Do Ó Pessoa, C. Synthesis and Biological Evaluation of Rigid Polycyclic Derivatives of the Diels-Alder Adduct Tricyclo[6.2.1.02,7]undeca-4,9-dien-3,6-dione. Molecules 2007, 12, 271-282.

AMA Style

Ito F.M., Petroni J.M., De Lima D.P., Beatriz A., Marques M.R., De Moraes M.O., Costa-Lotufo L.V., Montenegro R.C., Ferreira Magalhãe H.I., Do Ó Pessoa C. Synthesis and Biological Evaluation of Rigid Polycyclic Derivatives of the Diels-Alder Adduct Tricyclo[6.2.1.02,7]undeca-4,9-dien-3,6-dione. Molecules. 2007; 12(2):271-282.

Chicago/Turabian Style

Ito, Felicia M.; Petroni, Jacqueline M.; De Lima, Dênis P.; Beatriz, Adilson; Marques, Maria R.; De Moraes, Manoel O.; Costa-Lotufo, Letícia V.; Montenegro, Raquel C.; Ferreira Magalhãe, Hemerson I.; Do Ó Pessoa, Cláudia. 2007. "Synthesis and Biological Evaluation of Rigid Polycyclic Derivatives of the Diels-Alder Adduct Tricyclo[6.2.1.02,7]undeca-4,9-dien-3,6-dione." Molecules 12, no. 2: 271-282.

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