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Molecules 2007, 12(1), 114-129; doi:10.3390/12010114
Article

Synthesis of Functionalised Nucleosides for Incorporation into Nucleic Acid-Based Serine Protease Mimics

 and *
Ghent University, Department of Organic Chemistry, Laboratory for Organic and Biomimetic Chemistry, Krijgslaan 281 (S4), B-9000 Gent, Belgium
* Author to whom correspondence should be addressed.
Received: 21 December 2006 / Revised: 29 January 2007 / Accepted: 30 January 2007 / Published: 31 January 2007
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Abstract

The synthesis of nucleosides modified with an extra imidazole, carboxyl and hydroxyl group is described. These nucleosides can be incorporated into an oligonucleotide duplex, thus generating a novel type of serine protease mimic.
Keywords: Nucleoside synthesis; serine protease mimic; DNA scaffold; 2� modification. Nucleoside synthesis; serine protease mimic; DNA scaffold; 2� modification.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Catry, M.A.; Madder, A. Synthesis of Functionalised Nucleosides for Incorporation into Nucleic Acid-Based Serine Protease Mimics. Molecules 2007, 12, 114-129.

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