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Molecules 2007, 12(1), 103-113; doi:10.3390/12010103
Article

Synthesis and Antimicrobial Activity of Some New 1,3,4-Thiadiazole and 1,2,4-Triazole Compounds Having a D,L-Methionine Moiety

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Received: 4 December 2006; in revised form: 25 January 2007 / Accepted: 26 January 2007 / Published: 29 January 2007
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Abstract: New 1,3,4-thiadiazole, 5a-e, and 1,2,4-triazolecompounds 6a-c, containing a D,L-methionine moiety were synthesized by intramolecular cyclization of 1,4-disubstituted thiosemicarbazides 4a-e in acid and alkaline media, respectively. The potential antimicrobial effects of the synthesized compounds were investigated using the Staphylococcus aureus ATCC 25923, Bacillus antracis ATCC 8705, Bacillus cereus ATCC 10987, Sarcina lutea ATCC 9341 and Escherichia coli ATCC 25922 strains. The newly synthesized compounds exhibited promising activities against Bacillus antracis and Bacillus cereus.
Keywords: 1;3;4-Thiadiazole; 1;2;4-triazole; thiosemicarbazide; D;L-methionine; antimicrobial activity 1; 3; 4-Thiadiazole; 1; 2; 4-triazole; thiosemicarbazide; D; L-methionine; antimicrobial activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Pintilie, O.; Profire, L.; Sunel, V.; Popa, M.; Pui, A. Synthesis and Antimicrobial Activity of Some New 1,3,4-Thiadiazole and 1,2,4-Triazole Compounds Having a D,L-Methionine Moiety. Molecules 2007, 12, 103-113.

AMA Style

Pintilie O, Profire L, Sunel V, Popa M, Pui A. Synthesis and Antimicrobial Activity of Some New 1,3,4-Thiadiazole and 1,2,4-Triazole Compounds Having a D,L-Methionine Moiety. Molecules. 2007; 12(1):103-113.

Chicago/Turabian Style

Pintilie, Otilia; Profire, Lenuta; Sunel, Valeriu; Popa, Marcel; Pui, Aurel. 2007. "Synthesis and Antimicrobial Activity of Some New 1,3,4-Thiadiazole and 1,2,4-Triazole Compounds Having a D,L-Methionine Moiety." Molecules 12, no. 1: 103-113.


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