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Molecules 2007, 12(1), 103-113; doi:10.3390/12010103
Article

Synthesis and Antimicrobial Activity of Some New 1,3,4-Thiadiazole and 1,2,4-Triazole Compounds Having a D,L-Methionine Moiety

1
, 2,* , 1
, 3
 and 3
1 Department of Organic Chemistry and Biochemistry and 4 Department of Inorganic Chemistry; Faculty of Chemistry, “Al. I. Cuza” University, Bd. Carol I, no. 11, 700506 Iasi, Romania 2 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, “Gr. T. Popa” Medicine and Pharmacy University, Universitatii Street, no. 16, 700115 Iasi, Romania 3 Department of Natural and Synthetic Polymers, Faculty of Chemical Engineering, “Gh. Asachi” Technical University, Bd. Mangeron, no. 71A, 700050, Iasi, Romania
* Author to whom correspondence should be addressed.
Received: 4 December 2006 / Revised: 25 January 2007 / Accepted: 26 January 2007 / Published: 29 January 2007
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Abstract

New 1,3,4-thiadiazole, 5a-e, and 1,2,4-triazolecompounds 6a-c, containing a D,L-methionine moiety were synthesized by intramolecular cyclization of 1,4-disubstituted thiosemicarbazides 4a-e in acid and alkaline media, respectively. The potential antimicrobial effects of the synthesized compounds were investigated using the Staphylococcus aureus ATCC 25923, Bacillus antracis ATCC 8705, Bacillus cereus ATCC 10987, Sarcina lutea ATCC 9341 and Escherichia coli ATCC 25922 strains. The newly synthesized compounds exhibited promising activities against Bacillus antracis and Bacillus cereus.
Keywords: 1;3;4-Thiadiazole; 1;2;4-triazole; thiosemicarbazide; D;L-methionine; antimicrobial activity 1; 3; 4-Thiadiazole; 1; 2; 4-triazole; thiosemicarbazide; D; L-methionine; antimicrobial activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Pintilie, O.; Profire, L.; Sunel, V.; Popa, M.; Pui, A. Synthesis and Antimicrobial Activity of Some New 1,3,4-Thiadiazole and 1,2,4-Triazole Compounds Having a D,L-Methionine Moiety. Molecules 2007, 12, 103-113.

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