Radical-scavenging Activity of Natural Methoxyphenols vs. Synthetic Ones using the Induction Period Method

doi:10.3390/12020130

This article is

freely available
re-usable

Molecules 2007, 12(2), 130-138; doi:10.3390/12020130

Article

Radical-scavenging Activity of Natural Methoxyphenols vs. Synthetic Ones using the Induction Period Method

Yoshinori Kadoma ¹ , Toshiko Atsumi ² , Norihisa Okada ² , Mariko Ishihara ² , Ichiro Yokoe ³ and Seiichiro Fujisawa ²^,*

¹ Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Kandasurugadai, Chiyoda-ku, Tokyo 101-0062, Japan
² Meikai Unversity School of Dentistry, Sakado, Saitama 3500283, Japan
³ Faculty of Pharmaceutical Sciences, Josai University, Saitama 3500295, Japan

^* Author to whom correspondence should be addressed.

Received: 22 January 2007; in revised form: 31 January 2007 / Accepted: 1 February 2007 / Published: 3 February 2007

(This article belongs to the Special Issue Phenolics and Polyphenolics)

Download PDF Full-Text [110 KB, Version of Record, uploaded 20 June 2008 16:50 CET]

Abstract: The radical-scavenging activities of the synthetic antioxidants 2-allyl-4-X-phenol (X=NO₂, Cl, Br, OCH₃, COCH₃, CH₃, t-(CH₃)₃, C₆H₅) and 2,4-dimethoxyphenol, and the natural antioxidants eugenol and isoeugenol, were investigated using differential scanning calorimetry (DSC) by measuring their anti-1,1-diphenyl-2-picrylhydrazyl (DPPH) radical activity and the induction period for polymerization of methyl methacrylate (MMA) initiated by thermal decomposition of 2,2'-azobisisobutyronitrile (AIBN) and benzoyl peroxide (BPO). 2-Allyl-4-methoxyphenol and 2,4-dimethoxy-phenol scavenged not only oxygen-centered radicals (PhCOO^.) derived from BPO, but also carbon-centered radicals (R^.) derived from the AIBN and DPPH radical much more efficiently, in comparison with eugenol and isoeugenol. 2-Allyl-4-methoxyphenol may be useful for its lower prooxidative activity.

Keywords: Radical-scavenging activity; natural and synthetic methoxyphenols; DPPH; BPO;AIBN; induction method.

Article Statistics

Click here to load and display the download statistics.

Cite This Article

MDPI and ACS Style

Kadoma, Y.; Atsumi, T.; Okada, N.; Ishihara, M.; Yokoe, I.; Fujisawa, S. Radical-scavenging Activity of Natural Methoxyphenols vs. Synthetic Ones using the Induction Period Method. Molecules 2007, 12, 130-138.

AMA Style

Kadoma Y., Atsumi T., Okada N., Ishihara M., Yokoe I., Fujisawa S. Radical-scavenging Activity of Natural Methoxyphenols vs. Synthetic Ones using the Induction Period Method. Molecules. 2007; 12(2):130-138.

Chicago/Turabian Style

Kadoma, Yoshinori; Atsumi, Toshiko; Okada, Norihisa; Ishihara, Mariko; Yokoe, Ichiro; Fujisawa, Seiichiro. 2007. "Radical-scavenging Activity of Natural Methoxyphenols vs. Synthetic Ones using the Induction Period Method." Molecules 12, no. 2: 130-138.

Molecules EISSN 1420-3049 Published by MDPI Publishing, Basel, Switzerland RSS E-Mail Table of Contents Alert