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Molecules 2007, 12(2), 130-138; doi:10.3390/12020130

Radical-scavenging Activity of Natural Methoxyphenols vs. Synthetic Ones using the Induction Period Method

1 Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Kandasurugadai, Chiyoda-ku, Tokyo 101-0062, Japan 2 Meikai Unversity School of Dentistry, Sakado, Saitama 3500283, Japan 3 Faculty of Pharmaceutical Sciences, Josai University, Saitama 3500295, Japan
* Author to whom correspondence should be addressed.
Received: 22 January 2007 / Revised: 31 January 2007 / Accepted: 1 February 2007 / Published: 3 February 2007
(This article belongs to the Special Issue Phenolics and Polyphenolics)
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The radical-scavenging activities of the synthetic antioxidants 2-allyl-4-X-phenol (X=NO2, Cl, Br, OCH3, COCH3, CH3, t-(CH3)3, C6H5) and 2,4-dimethoxyphenol, and the natural antioxidants eugenol and isoeugenol, were investigated using differential scanning calorimetry (DSC) by measuring their anti-1,1-diphenyl-2-picrylhydrazyl (DPPH) radical activity and the induction period for polymerization of methyl methacrylate (MMA) initiated by thermal decomposition of 2,2'-azobisisobutyronitrile (AIBN) and benzoyl peroxide (BPO). 2-Allyl-4-methoxyphenol and 2,4-dimethoxy-phenol scavenged not only oxygen-centered radicals (PhCOO.) derived from BPO, but also carbon-centered radicals (R.) derived from the AIBN and DPPH radical much more efficiently, in comparison with eugenol and isoeugenol. 2-Allyl-4-methoxyphenol may be useful for its lower prooxidative activity.
Keywords: Radical-scavenging activity; natural and synthetic methoxyphenols; DPPH; BPO;AIBN; induction method. Radical-scavenging activity; natural and synthetic methoxyphenols; DPPH; BPO; AIBN; induction method.
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Kadoma, Y.; Atsumi, T.; Okada, N.; Ishihara, M.; Yokoe, I.; Fujisawa, S. Radical-scavenging Activity of Natural Methoxyphenols vs. Synthetic Ones using the Induction Period Method. Molecules 2007, 12, 130-138.

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