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Molecules 2007, 12(2), 130-138; doi:10.3390/12020130

Radical-scavenging Activity of Natural Methoxyphenols vs. Synthetic Ones using the Induction Period Method

1 Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Kandasurugadai, Chiyoda-ku, Tokyo 101-0062, Japan 2 Meikai Unversity School of Dentistry, Sakado, Saitama 3500283, Japan 3 Faculty of Pharmaceutical Sciences, Josai University, Saitama 3500295, Japan
* Author to whom correspondence should be addressed.
Received: 22 January 2007 / Revised: 31 January 2007 / Accepted: 1 February 2007 / Published: 3 February 2007
(This article belongs to the Special Issue Phenolics and Polyphenolics)
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The radical-scavenging activities of the synthetic antioxidants 2-allyl-4-X-phenol (X=NO2, Cl, Br, OCH3, COCH3, CH3, t-(CH3)3, C6H5) and 2,4-dimethoxyphenol, and the natural antioxidants eugenol and isoeugenol, were investigated using differential scanning calorimetry (DSC) by measuring their anti-1,1-diphenyl-2-picrylhydrazyl (DPPH) radical activity and the induction period for polymerization of methyl methacrylate (MMA) initiated by thermal decomposition of 2,2'-azobisisobutyronitrile (AIBN) and benzoyl peroxide (BPO). 2-Allyl-4-methoxyphenol and 2,4-dimethoxy-phenol scavenged not only oxygen-centered radicals (PhCOO.) derived from BPO, but also carbon-centered radicals (R.) derived from the AIBN and DPPH radical much more efficiently, in comparison with eugenol and isoeugenol. 2-Allyl-4-methoxyphenol may be useful for its lower prooxidative activity.
Keywords: Radical-scavenging activity; natural and synthetic methoxyphenols; DPPH; BPO;AIBN; induction method. Radical-scavenging activity; natural and synthetic methoxyphenols; DPPH; BPO; AIBN; induction method.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Kadoma, Y.; Atsumi, T.; Okada, N.; Ishihara, M.; Yokoe, I.; Fujisawa, S. Radical-scavenging Activity of Natural Methoxyphenols vs. Synthetic Ones using the Induction Period Method. Molecules 2007, 12, 130-138.

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