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Molecules 2006, 11(8), 649-654; doi:10.3390/11080649
Article

Efficient Ce(NO3)3·6H2O-Catalyzed Solvent-Free Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones

* , ,  and
Received: 27 October 2005 / Revised: 9 May 2006 / Accepted: 23 August 2006 / Published: 23 August 2006
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Abstract

Cerium(III) nitrate hexahydrate efficiently catalyzes the three-component Biginelli reaction under solvent-free conditions of an aldehyde, a β-keto ester or β- diketone and urea or thiourea to afford the corresponding 3,4-dihydropyrimidin-2(1H)- ones or –thiones in excellent yields.
Keywords: Dihydropyrimidinones; cerium(III) nitrate; Biginelli reaction; solvent-free synthesis. Dihydropyrimidinones; cerium(III) nitrate; Biginelli reaction; solvent-free synthesis.
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Adib, M.; Ghanbary, K.; Mostofi, M.; Ganjali, M.R. Efficient Ce(NO3)3·6H2O-Catalyzed Solvent-Free Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones. Molecules 2006, 11, 649-654.

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