Next Article in Journal
Formal Synthesis of the ACE Inhibitor Benazepril·HCl via an Asymmetric Aza-Michael Reaction
Previous Article in Journal
Synthesis of Conformationally Constrained Aryl- or Heteroarylpiperazinyl Derivatives of Selected Imides as 5-HT1A Receptor Ligands
Molecules 2006, 11(8), 627-640; doi:10.3390/11080627

Development of Fluorous Lewis Acid-Catalyzed Reactions

, 1, 1 and 1
Received: 5 July 2006 / Revised: 26 July 2006 / Accepted: 26 July 2006 / Published: 23 August 2006
Download PDF [326 KB, uploaded 18 June 2014]
Abstract: Organic synthetic methodology in the 21st century aims to conform to the principles of green sustainable chemistry (GSC) and we may expect that in the future, the realization of GSC will be an important objective for chemical industries. An important aim of synthetic organic chemistry is to implement waste-free and environmentally-benign industrial processes using Lewis acids as versatile as aluminum choride. A key technological objective of our work in this area has been to achieve a “catalyst recycling system that utilizes the high activity and structural features of fluorous Lewis acid catalysts”. Thus, we have developed a series of novel fluorous Lewis acid catalysts, namely the ytterbium(III), scandium(III), tin(IV) or hafnium(IV) bis(perfluoroalkanesulfonyl)amides or tris(perfluoro- alkanesulfonyl)methides. Our catalysts are recyclable and effective for acylations of alcohols and aromatics, Baeyer-Villiger reactions, direct esterifications and transesterifications in a fluorous biphasic system (FBS), in supercritical carbon dioxide and on fluorous silica gel supports.
Keywords: Fluorous chemistry; Lewis acid; sulfonimide; biphasic system; aqueous reaction. Fluorous chemistry; Lewis acid; sulfonimide; biphasic system; aqueous reaction.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |

MDPI and ACS Style

Yoshida, A.; Hao, X.; Yamazaki, O.; Nishikido, J. Development of Fluorous Lewis Acid-Catalyzed Reactions. Molecules 2006, 11, 627-640.

AMA Style

Yoshida A, Hao X, Yamazaki O, Nishikido J. Development of Fluorous Lewis Acid-Catalyzed Reactions. Molecules. 2006; 11(8):627-640.

Chicago/Turabian Style

Yoshida, Akihiro; Hao, Xiuhua; Yamazaki, Osamu; Nishikido, Joji. 2006. "Development of Fluorous Lewis Acid-Catalyzed Reactions." Molecules 11, no. 8: 627-640.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert