Molecules 2006, 11(8), 615-626; doi:10.3390/11080615
Article

Synthesis of Conformationally Constrained Aryl- or Heteroarylpiperazinyl Derivatives of Selected Imides as 5-HT1A Receptor Ligands

Department of Medical Chemistry, Medical University, 3 Oczki St., 02-007 Warsaw, Poland
* Author to whom correspondence should be addressed.
Received: 14 June 2006; in revised form: 3 August 2006 / Accepted: 11 August 2006 / Published: 23 August 2006
PDF Full-text Download PDF Full-Text [90 KB, uploaded 20 June 2008 16:50 CEST]
Abstract: The preparation of a number of cyclic imide 5-HT1A receptor ligandderivatives has been described. Their structures were conformationally constrained byintroducing rigid linkers containing unsaturated bonds or aromatic benzene rings. Thesecompounds are expected to possess anxiolytic and antidepressant activity.
Keywords: Conformational constraints; cis- and trans-2-butene derivatives; 1; 2- bismethylbenzene derivatives; imides; 5-HT1A receptor ligands.

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

Kossakowski, J.; Krawiecka, M.; Kuran, B. Synthesis of Conformationally Constrained Aryl- or Heteroarylpiperazinyl Derivatives of Selected Imides as 5-HT1A Receptor Ligands. Molecules 2006, 11, 615-626.

AMA Style

Kossakowski J, Krawiecka M, Kuran B. Synthesis of Conformationally Constrained Aryl- or Heteroarylpiperazinyl Derivatives of Selected Imides as 5-HT1A Receptor Ligands. Molecules. 2006; 11(8):615-626.

Chicago/Turabian Style

Kossakowski, Jerzy; Krawiecka, Mariola; Kuran, Bożena. 2006. "Synthesis of Conformationally Constrained Aryl- or Heteroarylpiperazinyl Derivatives of Selected Imides as 5-HT1A Receptor Ligands." Molecules 11, no. 8: 615-626.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert