Next Article in Journal
Development of Fluorous Lewis Acid-Catalyzed Reactions
Previous Article in Journal
Epibatidine Alkaloid Chemistry: 5. Domino-Heck Reactions of Azabicyclic and Tricyclic Systems
Article Menu

Export Article

Open AccessArticle
Molecules 2006, 11(8), 615-626; doi:10.3390/11080615

Synthesis of Conformationally Constrained Aryl- or Heteroarylpiperazinyl Derivatives of Selected Imides as 5-HT1A Receptor Ligands

Department of Medical Chemistry, Medical University, 3 Oczki St., 02-007 Warsaw, Poland
*
Author to whom correspondence should be addressed.
Received: 14 June 2006 / Revised: 3 August 2006 / Accepted: 11 August 2006 / Published: 23 August 2006
View Full-Text   |   Download PDF [90 KB, uploaded 18 June 2014]   |  

Abstract

The preparation of a number of cyclic imide 5-HT1A receptor ligandderivatives has been described. Their structures were conformationally constrained byintroducing rigid linkers containing unsaturated bonds or aromatic benzene rings. Thesecompounds are expected to possess anxiolytic and antidepressant activity.
Keywords: Conformational constraints; cis- and trans-2-butene derivatives; 1; 2- bismethylbenzene derivatives; imides; 5-HT1A receptor ligands. Conformational constraints; cis- and trans-2-butene derivatives; 1; 2- bismethylbenzene derivatives; imides; 5-HT1A receptor ligands.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Kossakowski, J.; Krawiecka, M.; Kuran, B. Synthesis of Conformationally Constrained Aryl- or Heteroarylpiperazinyl Derivatives of Selected Imides as 5-HT1A Receptor Ligands. Molecules 2006, 11, 615-626.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top