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Molecules 2006, 11(8), 615-626; doi:10.3390/11080615
Article

Synthesis of Conformationally Constrained Aryl- or Heteroarylpiperazinyl Derivatives of Selected Imides as 5-HT1A Receptor Ligands

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Received: 14 June 2006; in revised form: 3 August 2006 / Accepted: 11 August 2006 / Published: 23 August 2006
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Abstract: The preparation of a number of cyclic imide 5-HT1A receptor ligandderivatives has been described. Their structures were conformationally constrained byintroducing rigid linkers containing unsaturated bonds or aromatic benzene rings. Thesecompounds are expected to possess anxiolytic and antidepressant activity.
Keywords: Conformational constraints; cis- and trans-2-butene derivatives; 1; 2- bismethylbenzene derivatives; imides; 5-HT1A receptor ligands. Conformational constraints; cis- and trans-2-butene derivatives; 1; 2- bismethylbenzene derivatives; imides; 5-HT1A receptor ligands.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Kossakowski, J.; Krawiecka, M.; Kuran, B. Synthesis of Conformationally Constrained Aryl- or Heteroarylpiperazinyl Derivatives of Selected Imides as 5-HT1A Receptor Ligands. Molecules 2006, 11, 615-626.

AMA Style

Kossakowski J, Krawiecka M, Kuran B. Synthesis of Conformationally Constrained Aryl- or Heteroarylpiperazinyl Derivatives of Selected Imides as 5-HT1A Receptor Ligands. Molecules. 2006; 11(8):615-626.

Chicago/Turabian Style

Kossakowski, Jerzy; Krawiecka, Mariola; Kuran, Bożena. 2006. "Synthesis of Conformationally Constrained Aryl- or Heteroarylpiperazinyl Derivatives of Selected Imides as 5-HT1A Receptor Ligands." Molecules 11, no. 8: 615-626.


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