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Molecules 2006, 11(6), 478-485; doi:10.3390/11060478

Host-Guest Chemistry of Tolbutamide

* , *  and
Departamento de Química Orgánica y Bio-Orgánica, Universidad Nacional de Educación a Distancia (UNED), Facultad de Ciencias, Senda del Rey 9, E-28040 Madrid, Spain
* Authors to whom correspondence should be addressed.
Received: 29 April 2006 / Revised: 13 June 2006 / Accepted: 15 June 2006 / Published: 23 June 2006
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The molecular recognition features of tolbutamide with four synthetic hosts have been studied by means of NMR titrations, NOESY experiments and Monte Carlo (MC) conformational search. The interaction strength and the most probable structure reveal new insights on the recognition phenomena of this urea derivative in comparison with close related compounds.
Keywords: Molecular Recognition; Monte Carlo conformational search; NMR titrations; tolbutamide. Molecular Recognition; Monte Carlo conformational search; NMR titrations; tolbutamide.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Herranz, F.; Santa María, M.D.; Claramunt, R.M. Host-Guest Chemistry of Tolbutamide. Molecules 2006, 11, 478-485.

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