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Solid Phase Synthesis of a Metronidazole Oligonucleotide Conjugate
School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham, B4 7ET, UK
* Author to whom correspondence should be addressed.
Received: 26 April 2006; in revised form: 23 May 2006 / Accepted: 29 May 2006 / Published: 23 June 2006
Abstract: Direct, solid phase synthesis of an oligonucleotide conjugate of the antibioticdrug metronidazole was accomplished by the phosphoramidite method. Removal ofprotecting groups and cleavage from the controlled pore glass (CPG) solid support wassuccessful using mild conditions (20% Et3N in pyridine, then conc. NH3 (aq) at rt for 30min) whereas standard conditions (conc. NH3 (aq) at 55 °C for 16 h) cleaved the drug.
Keywords: CPG; conjugate; metronidazole; oligonucleotide; phosphoramidite; solid phase.
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MDPI and ACS Style
Walsh, A.J.; Davis, M.L.; Fraser, W. Solid Phase Synthesis of a Metronidazole Oligonucleotide Conjugate. Molecules 2006, 11, 486-495.
Walsh AJ, Davis ML, Fraser W. Solid Phase Synthesis of a Metronidazole Oligonucleotide Conjugate. Molecules. 2006; 11(6):486-495.
Walsh, Andrew J.; Davis, Michael L.; Fraser, William. 2006. "Solid Phase Synthesis of a Metronidazole Oligonucleotide Conjugate." Molecules 11, no. 6: 486-495.