Molecules 2006, 11(6), 486-495; doi:10.3390/11060486
Article

Solid Phase Synthesis of a Metronidazole Oligonucleotide Conjugate

School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham, B4 7ET, UK
* Author to whom correspondence should be addressed.
Received: 26 April 2006; in revised form: 23 May 2006 / Accepted: 29 May 2006 / Published: 23 June 2006
PDF Full-text Download PDF Full-Text [76 KB, uploaded 20 June 2008 16:50 CEST]
Abstract: Direct, solid phase synthesis of an oligonucleotide conjugate of the antibioticdrug metronidazole was accomplished by the phosphoramidite method. Removal ofprotecting groups and cleavage from the controlled pore glass (CPG) solid support wassuccessful using mild conditions (20% Et3N in pyridine, then conc. NH3 (aq) at rt for 30min) whereas standard conditions (conc. NH3 (aq) at 55 °C for 16 h) cleaved the drug.
Keywords: CPG; conjugate; metronidazole; oligonucleotide; phosphoramidite; solid phase.

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

Walsh, A.J.; Davis, M.L.; Fraser, W. Solid Phase Synthesis of a Metronidazole Oligonucleotide Conjugate. Molecules 2006, 11, 486-495.

AMA Style

Walsh AJ, Davis ML, Fraser W. Solid Phase Synthesis of a Metronidazole Oligonucleotide Conjugate. Molecules. 2006; 11(6):486-495.

Chicago/Turabian Style

Walsh, Andrew J.; Davis, Michael L.; Fraser, William. 2006. "Solid Phase Synthesis of a Metronidazole Oligonucleotide Conjugate." Molecules 11, no. 6: 486-495.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert