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Molecules 2006, 11(6), 486-495; doi:10.3390/11060486
Article

Solid Phase Synthesis of a Metronidazole Oligonucleotide Conjugate

,  and *
Received: 26 April 2006 / Revised: 23 May 2006 / Accepted: 29 May 2006 / Published: 23 June 2006
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Abstract

Direct, solid phase synthesis of an oligonucleotide conjugate of the antibioticdrug metronidazole was accomplished by the phosphoramidite method. Removal ofprotecting groups and cleavage from the controlled pore glass (CPG) solid support wassuccessful using mild conditions (20% Et3N in pyridine, then conc. NH3 (aq) at rt for 30min) whereas standard conditions (conc. NH3 (aq) at 55 °C for 16 h) cleaved the drug.
Keywords: CPG; conjugate; metronidazole; oligonucleotide; phosphoramidite; solid phase. CPG; conjugate; metronidazole; oligonucleotide; phosphoramidite; solid phase.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Walsh, A.J.; Davis, M.L.; Fraser, W. Solid Phase Synthesis of a Metronidazole Oligonucleotide Conjugate. Molecules 2006, 11, 486-495.

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