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Molecules 2006, 11(6), 486-495; doi:10.3390/11060486

Solid Phase Synthesis of a Metronidazole Oligonucleotide Conjugate

School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham, B4 7ET, UK
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Received: 26 April 2006 / Revised: 23 May 2006 / Accepted: 29 May 2006 / Published: 23 June 2006
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Abstract

Direct, solid phase synthesis of an oligonucleotide conjugate of the antibioticdrug metronidazole was accomplished by the phosphoramidite method. Removal ofprotecting groups and cleavage from the controlled pore glass (CPG) solid support wassuccessful using mild conditions (20% Et3N in pyridine, then conc. NH3 (aq) at rt for 30min) whereas standard conditions (conc. NH3 (aq) at 55 °C for 16 h) cleaved the drug.
Keywords: CPG; conjugate; metronidazole; oligonucleotide; phosphoramidite; solid phase. CPG; conjugate; metronidazole; oligonucleotide; phosphoramidite; solid phase.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Walsh, A.J.; Davis, M.L.; Fraser, W. Solid Phase Synthesis of a Metronidazole Oligonucleotide Conjugate. Molecules 2006, 11, 486-495.

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