Molecules 2006, 11(2), 148-155; doi:10.3390/11020148
Article

Synthesis and Antidepressant Evaluation of Three para-Benzoquinone Mono-oximes and Their Oxy Derivatives

Damião Pergentino De Sousa* email, Renata Rabelo Schefer, Ursula Brocksom and Timothy John Brocksom* email
Laboratório de Química Bio-Orgânica, Departamento de Química, Universidade Federal de São Carlos, Caixa Postal 676, 13565-905 São Carlos, SP, Brazil
* Authors to whom correspondence should be addressed.
Received: 18 January 2006 / Accepted: 7 March 2006 / Published: 10 March 2006
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Abstract: A series of three para-benzoquinone mono-oximes and four oxy-derivatives were prepared and tested for their antidepressant properties. The (4E) oxime of 2-isopropyl-5- methyl-para-benzoquinone (4) and the corresponding 2-diethylamino-ethyl derivative (10) present antidepressant activities and were slightly more potent than the reference standard.
Keywords: Oximes; para-benzoquinones; antidepressant activity.

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MDPI and ACS Style

De Sousa, D.P.; Schefer, R.R.; Brocksom, U.; Brocksom, T.J. Synthesis and Antidepressant Evaluation of Three para-Benzoquinone Mono-oximes and Their Oxy Derivatives. Molecules 2006, 11, 148-155.

AMA Style

De Sousa DP, Schefer RR, Brocksom U, Brocksom TJ. Synthesis and Antidepressant Evaluation of Three para-Benzoquinone Mono-oximes and Their Oxy Derivatives. Molecules. 2006; 11(2):148-155.

Chicago/Turabian Style

De Sousa, Damião P.; Schefer, Renata R.; Brocksom, Ursula; Brocksom, Timothy J. 2006. "Synthesis and Antidepressant Evaluation of Three para-Benzoquinone Mono-oximes and Their Oxy Derivatives." Molecules 11, no. 2: 148-155.

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