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Molecules 2006, 11(2), 148-155; doi:10.3390/11020148

Synthesis and Antidepressant Evaluation of Three para-Benzoquinone Mono-oximes and Their Oxy Derivatives

* , ,  and *
Laboratório de Química Bio-Orgânica, Departamento de Química, Universidade Federal de São Carlos, Caixa Postal 676, 13565-905 São Carlos, SP, Brazil
* Authors to whom correspondence should be addressed.
Received: 18 January 2006 / Accepted: 7 March 2006 / Published: 10 March 2006
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A series of three para-benzoquinone mono-oximes and four oxy-derivatives were prepared and tested for their antidepressant properties. The (4E) oxime of 2-isopropyl-5- methyl-para-benzoquinone (4) and the corresponding 2-diethylamino-ethyl derivative (10) present antidepressant activities and were slightly more potent than the reference standard.
Keywords: Oximes; para-benzoquinones; antidepressant activity. Oximes; para-benzoquinones; antidepressant activity.
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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De Sousa, D.P.; Schefer, R.R.; Brocksom, U.; Brocksom, T.J. Synthesis and Antidepressant Evaluation of Three para-Benzoquinone Mono-oximes and Their Oxy Derivatives. Molecules 2006, 11, 148-155.

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