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Molecules 2006, 11(10), 739-750; doi:10.3390/11100739
Article

A Simple Synthesis of 2-Thiohydantoins

* ,  and
Department of Chemistry, University of Houston-Clear Lake, 2700 Bay Area Boulevard, Houston, TX 77058, U.S.A.
* Author to whom correspondence should be addressed.
Received: 9 August 2006 / Revised: 24 August 2006 / Accepted: 24 August 2006 / Published: 2 October 2006
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Abstract

2-Thiohydantoin derivatives are produced by heating a mixture of thiourea and an α-amino acid. The method described offers the advantages of simplicity, low cost, easy work-up and scalability.
Keywords: Amino acids; Antiviral agents; Cyclization; Heterocycles; 2-Thiohydantoin Amino acids; Antiviral agents; Cyclization; Heterocycles; 2-Thiohydantoin
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Wang, Z.D.; Sheikh, S.O.; Zhang, Y. A Simple Synthesis of 2-Thiohydantoins. Molecules 2006, 11, 739-750.

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