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Molecules 2006, 11(10), 739-750; doi:10.3390/11100739
Article

A Simple Synthesis of 2-Thiohydantoins

* ,  and
Department of Chemistry, University of Houston-Clear Lake, 2700 Bay Area Boulevard, Houston, TX 77058, U.S.A.
* Author to whom correspondence should be addressed.
Received: 9 August 2006 / Revised: 24 August 2006 / Accepted: 24 August 2006 / Published: 2 October 2006
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Abstract

2-Thiohydantoin derivatives are produced by heating a mixture of thiourea and an α-amino acid. The method described offers the advantages of simplicity, low cost, easy work-up and scalability.
Keywords: Amino acids; Antiviral agents; Cyclization; Heterocycles; 2-Thiohydantoin Amino acids; Antiviral agents; Cyclization; Heterocycles; 2-Thiohydantoin
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Wang, Z.D.; Sheikh, S.O.; Zhang, Y. A Simple Synthesis of 2-Thiohydantoins. Molecules 2006, 11, 739-750.

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