Molecules 2006, 11(10), 739-750; doi:10.3390/11100739
Article

A Simple Synthesis of 2-Thiohydantoins

Zerong Daniel Wang* email, Samia O. Sheikh and Yulu Zhang
Department of Chemistry, University of Houston-Clear Lake, 2700 Bay Area Boulevard, Houston, TX 77058, U.S.A.
* Author to whom correspondence should be addressed.
Received: 9 August 2006; in revised form: 24 August 2006 / Accepted: 24 August 2006 / Published: 2 October 2006
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Abstract: 2-Thiohydantoin derivatives are produced by heating a mixture of thiourea and an α-amino acid. The method described offers the advantages of simplicity, low cost, easy work-up and scalability.
Keywords: Amino acids; Antiviral agents; Cyclization; Heterocycles; 2-Thiohydantoin

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Cite This Article

MDPI and ACS Style

Wang, Z.D.; Sheikh, S.O.; Zhang, Y. A Simple Synthesis of 2-Thiohydantoins. Molecules 2006, 11, 739-750.

AMA Style

Wang ZD, Sheikh SO, Zhang Y. A Simple Synthesis of 2-Thiohydantoins. Molecules. 2006; 11(10):739-750.

Chicago/Turabian Style

Wang, Zerong D.; Sheikh, Samia O.; Zhang, Yulu. 2006. "A Simple Synthesis of 2-Thiohydantoins." Molecules 11, no. 10: 739-750.

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