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Molecules 2006, 11(10), 731-738; doi:10.3390/11100731
Article

Sulfated Zirconia-Catalyzed Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones (DHPMs) Under Solventless Conditions: Competitive Multicomponent Biginelli vs. Hantzsch Reactions

1
, 2
, 2
, 2
 and 1,*
1 Departamento de Ciencias Básicas, UAM, Av. San Pablo No 180. C. P. 02200, México 2 Departamento de Química, UAM, Av. San Pablo No 180. C. P. 02200, México
* Author to whom correspondence should be addressed.
Received: 21 July 2006 / Accepted: 27 September 2006 / Published: 2 October 2006
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Abstract

The catalytic ability of ZrO2/SO42- to promote solventless three-componentcondensation reactions of a diversity of aromatic aldehydes, urea or thoiurea and ethylacetoacetate was studied. Products resulting from Hantzsch and/or Biginelli multi-component reactions are obtained in the presence of solid acid catalysts using the samereactants but different temperature conditions. The sulfated zirconia catalyst can berecovered and recycled in subsequent reactions with a gradual decrease of activity.
Keywords: Biginelli reaction; Hantzsch reaction ; multicomponent reactions; 1; 4- dihydropyridines; dihydropyrimidinones; solventless reactions. Biginelli reaction; Hantzsch reaction; multicomponent reactions; 1; 4- dihydropyridines; dihydropyrimidinones; solventless reactions.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Angeles-Beltrán, D.; Lomas-Romero, L.; Lara-Corona, V.H.; González-Zamora, E.; Negrón-Silva, G. Sulfated Zirconia-Catalyzed Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones (DHPMs) Under Solventless Conditions: Competitive Multicomponent Biginelli vs. Hantzsch Reactions. Molecules 2006, 11, 731-738.

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