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Molecules 2006, 11(10), 731-738; doi:10.3390/11100731

Sulfated Zirconia-Catalyzed Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones (DHPMs) Under Solventless Conditions: Competitive Multicomponent Biginelli vs. Hantzsch Reactions

1
Departamento de Ciencias Básicas, UAM, Av. San Pablo No 180. C. P. 02200, México
2
Departamento de Química, UAM, Av. San Pablo No 180. C. P. 02200, México
*
Author to whom correspondence should be addressed.
Received: 21 July 2006 / Accepted: 27 September 2006 / Published: 2 October 2006
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Abstract

The catalytic ability of ZrO2/SO42- to promote solventless three-componentcondensation reactions of a diversity of aromatic aldehydes, urea or thoiurea and ethylacetoacetate was studied. Products resulting from Hantzsch and/or Biginelli multi-component reactions are obtained in the presence of solid acid catalysts using the samereactants but different temperature conditions. The sulfated zirconia catalyst can berecovered and recycled in subsequent reactions with a gradual decrease of activity. View Full-Text
Keywords: Biginelli reaction; Hantzsch reaction ; multicomponent reactions; 1; 4- dihydropyridines; dihydropyrimidinones; solventless reactions. Biginelli reaction; Hantzsch reaction ; multicomponent reactions; 1; 4- dihydropyridines; dihydropyrimidinones; solventless reactions.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Angeles-Beltrán, D.; Lomas-Romero, L.; Lara-Corona, V.H.; González-Zamora, E.; Negrón-Silva, G. Sulfated Zirconia-Catalyzed Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones (DHPMs) Under Solventless Conditions: Competitive Multicomponent Biginelli vs. Hantzsch Reactions. Molecules 2006, 11, 731-738.

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