Next Article in Journal / Special Issue
The tert-Amino Effect in Heterocyclic Chemistry. Synthesis of Spiro Heterocycles
Previous Article in Journal / Special Issue
An Improved Synthesis of Some 5-Substituted Indolizines Using Regiospecific Lithiation
Article Menu

Export Article

Open AccessArticle
Molecules 2005, 10(9), 1084-1100; doi:10.3390/10091084

Studies Towards the Total Synthesis of Di- and Sesterterpenes with Dicyclopenta[a,d]cyclooctane Skeletons. Three-component Approach to the A/B Rings Building Block

Institute of Organic Chemistry, Polish Academy of Sciences, Poland
*
Author to whom correspondence should be addressed.
Received: 23 April 2005 / Accepted: 30 September 2005 / Published: 30 September 2005

Abstract

Sesqui- and sesterterpenes of ophiobolin and fusicoccin families are important synthetic targets because of complexity of structure and potentially useful physiological activities, including anti-tumor activity. A synthesis of versatile building blocks for these terpenoids is described. Cyclopenta[8]annulene rings system with properly dislocated substituents was constructed using as key steps ring closing metathesis reaction and Wagner - Meerwein rearrangement. Ring closing metathesis reaction leading to cyclopenta[8]annulene was studied in detail. View Full-Text
Keywords: Terpenes; total synthesis; cyclooctane derivatives; ring closing metathesis; Warner-Meerwein rearrangement. Terpenes; total synthesis; cyclooctane derivatives; ring closing metathesis; Warner-Meerwein rearrangement.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Michalak, K.; Michalak, M.; Wicha, J. Studies Towards the Total Synthesis of Di- and Sesterterpenes with Dicyclopenta[a,d]cyclooctane Skeletons. Three-component Approach to the A/B Rings Building Block. Molecules 2005, 10, 1084-1100.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top