Molecules 2005, 10(9), 1084-1100; doi:10.3390/10091084
Article

Studies Towards the Total Synthesis of Di- and Sesterterpenes with Dicyclopenta[a,d]cyclooctane Skeletons. Three-component Approach to the A/B Rings Building Block

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Received: 23 April 2005; Accepted: 30 September 2005 / Published: 30 September 2005
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Sesqui- and sesterterpenes of ophiobolin and fusicoccin families are important synthetic targets because of complexity of structure and potentially useful physiological activities, including anti-tumor activity. A synthesis of versatile building blocks for these terpenoids is described. Cyclopenta[8]annulene rings system with properly dislocated substituents was constructed using as key steps ring closing metathesis reaction and Wagner - Meerwein rearrangement. Ring closing metathesis reaction leading to cyclopenta[8]annulene was studied in detail.
Keywords: Terpenes; total synthesis; cyclooctane derivatives; ring closing metathesis; Warner-Meerwein rearrangement.
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MDPI and ACS Style

Michalak, K.; Michalak, M.; Wicha, J. Studies Towards the Total Synthesis of Di- and Sesterterpenes with Dicyclopenta[a,d]cyclooctane Skeletons. Three-component Approach to the A/B Rings Building Block. Molecules 2005, 10, 1084-1100.

AMA Style

Michalak K, Michalak M, Wicha J. Studies Towards the Total Synthesis of Di- and Sesterterpenes with Dicyclopenta[a,d]cyclooctane Skeletons. Three-component Approach to the A/B Rings Building Block. Molecules. 2005; 10(9):1084-1100.

Chicago/Turabian Style

Michalak, K.; Michalak, M.; Wicha, J. 2005. "Studies Towards the Total Synthesis of Di- and Sesterterpenes with Dicyclopenta[a,d]cyclooctane Skeletons. Three-component Approach to the A/B Rings Building Block." Molecules 10, no. 9: 1084-1100.


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