The tert-Amino Effect in Heterocyclic Chemistry. Synthesis of Spiro Heterocycles

doi:10.3390/10091101

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Molecules 2005, 10(9), 1101-1108; doi:10.3390/10091101

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The tert-Amino Effect in Heterocyclic Chemistry. Synthesis of Spiro Heterocycles

E. D’yachenko, T. Glukhareva, L. Dyudya, O. Eltsov and Y. Morzherin*

Department of Technology for Organic Synthesis (TOSLab), Urals State Technical University, Russia

* Author to whom correspondence should be addressed.

Received: 23 April 2005 / Accepted: 30 September 2005 / Published: 30 September 2005

(This article belongs to the Special Issue Selected Papers from the “2nd International Conference on Natural Products and Physiologically Active Substances” (ICNPAS-2004) and the 3rd EuroAsian Heterocyclic Meeting “Heterocycles in Organic and Combinatorial Chemistry”)

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Abstract: The tert-amino reaction effect was examined. A new method to synthesize spiro heterocycles is presented. It was shown that the “tert-amino effect” could be applied to the formation of spiro-fused heterocycles. The formation of spiro compounds proceeds in most cases in good yields in a one-pot reaction.

Keywords: Tert-amino effect; cyclization; spiro compounds; Knoevenagel condensation; 1; 2; 3-thiadiazole; pyrazole; quinoline

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MDPI and ACS Style

D’yachenko, E.; Glukhareva, T.; Dyudya, L.; Eltsov, O.; Morzherin, Y. The tert-Amino Effect in Heterocyclic Chemistry. Synthesis of Spiro Heterocycles. Molecules 2005, 10, 1101-1108.

AMA Style

D’yachenko E, Glukhareva T, Dyudya L, Eltsov O, Morzherin Y. The tert-Amino Effect in Heterocyclic Chemistry. Synthesis of Spiro Heterocycles. Molecules. 2005; 10(9):1101-1108.

Chicago/Turabian Style

D’yachenko, E.; Glukhareva, T.; Dyudya, L.; Eltsov, O.; Morzherin, Y. 2005. "The tert-Amino Effect in Heterocyclic Chemistry. Synthesis of Spiro Heterocycles." Molecules 10, no. 9: 1101-1108.

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