A Novel Aromatic Iodination Method, with Sodium Periodate Used as the Only Iodinating Reagent

doi:10.3390/10030516

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Molecules 2005, 10(3), 516-520; doi:10.3390/10030516

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A Novel Aromatic Iodination Method, with Sodium Periodate Used as the Only Iodinating Reagent

Piotr Luliński, Maciej Sosnowski and Lech Skulski *

Chair and Laboratory of Organic Chemistry, Faculty of Pharmacy, Medical University, Banacha 1, PL 02-097 Warsaw, Poland

* Author to whom correspondence should be addressed.

Received: 10 November 2004 / Accepted: 10 March 2005 / Published: 13 May 2005

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Abstract: Benzene, halobenzenes and some deactivated arenes readily reacted inanhydrous NaIO₄/AcOH/Ac₂O/concd. H₂SO₄ mixtures to afford, after quenching withexcess aqueous Na₂SO₃ solution (a reducing agent), purified iodinated products in 27-88% yields. This novel method of aromatic iodination is simple, fairly effective andenvironmentally safe.

Keywords: Arenes; iodoarenes; aromatic iodination; sodium periodate; periodyl organic intermediates.

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MDPI and ACS Style

Luliński, P.; Sosnowski, M.; Skulski, L. A Novel Aromatic Iodination Method, with Sodium Periodate Used as the Only Iodinating Reagent. Molecules 2005, 10, 516-520.

AMA Style

Luliński P., Sosnowski M., Skulski L. A Novel Aromatic Iodination Method, with Sodium Periodate Used as the Only Iodinating Reagent. Molecules. 2005; 10(3):516-520.

Chicago/Turabian Style

Luliński, Piotr; Sosnowski, Maciej; Skulski, Lech. 2005. "A Novel Aromatic Iodination Method, with Sodium Periodate Used as the Only Iodinating Reagent." Molecules 10, no. 3: 516-520.

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