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Molecules 2005, 10(3), 516-520; doi:10.3390/10030516
Article

A Novel Aromatic Iodination Method, with Sodium Periodate Used as the Only Iodinating Reagent

,  and *
Chair and Laboratory of Organic Chemistry, Faculty of Pharmacy, Medical University, Banacha 1, PL 02-097 Warsaw, Poland
* Author to whom correspondence should be addressed.
Received: 10 November 2004 / Accepted: 10 March 2005 / Published: 13 May 2005
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Abstract

Benzene, halobenzenes and some deactivated arenes readily reacted inanhydrous NaIO4/AcOH/Ac2O/concd. H2SO4 mixtures to afford, after quenching withexcess aqueous Na2SO3 solution (a reducing agent), purified iodinated products in 27-88% yields. This novel method of aromatic iodination is simple, fairly effective andenvironmentally safe.
Keywords: Arenes; iodoarenes; aromatic iodination; sodium periodate; periodyl organic intermediates. Arenes; iodoarenes; aromatic iodination; sodium periodate; periodyl organic intermediates.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Luliński, P.; Sosnowski, M.; Skulski, L. A Novel Aromatic Iodination Method, with Sodium Periodate Used as the Only Iodinating Reagent. Molecules 2005, 10, 516-520.

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