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Molecules 2005, 10(1), 146-161; doi:10.3390/10010146

Biodegradable Polymers for Microencapsulation of Drugs

Department of Pharmaceutics and Biomedical Engineering, Purdue University, U.S.A
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Author to whom correspondence should be addressed.
Received: 25 June 2004 / Accepted: 1 July 2004 / Published: 31 January 2005
(This article belongs to the Special Issue Macromolecules Applied to Pharmaceutical Chemistry)
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Abstract

Drug delivery has become increasingly important mainly due to the awareness of the difficulties associated with a variety of old and new drugs. Of the many polymeric drug delivery systems, biodegradable polymers have been used widely as drug delivery systems because of their biocompatibility and biodegradability. The majority of biodegradable polymers have been used in the form of microparticles, from which the incorporated drug is released to the environment in a controlled manner. The factors responsible for controlling the drug release rate are physicochemical properties of drugs, degradation rate of polymers, and the morphology and size of microparticles. This review discusses the conventional and recent technologies for microencapsulation of the drugs using biodegradable polymers. In addition, this review presents characteristics and degradation behaviors of biodegradable polymers which are currently used in drug delivery.
Keywords: Microencapsulation technology; biodegradable polymer; drug delivery system. Microencapsulation technology; biodegradable polymer; drug delivery system.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Park, J.; Ye, M.; Park, K. Biodegradable Polymers for Microencapsulation of Drugs. Molecules 2005, 10, 146-161.

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