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Molecules 2005, 10(1), 162-180; doi:10.3390/10010162

Optimization of Protein Therapies by Polymer-Conjugation as an Effective DDS

1
Graduate School of Pharmaceutical Sciences, Osaka University. 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan
2
National Institute of Health Sciences, Osaka Branch Fundamental Research Laboratories for Development of Medicine. 7-6-8 Saito-Asagi, Ibaraki, Osaka 567-0085 Japan
*
Author to whom correspondence should be addressed.
Received: 30 June 2004 / Revised: 27 September 2004 / Accepted: 12 December 2004 / Published: 31 January 2005
(This article belongs to the Special Issue Macromolecules Applied to Pharmaceutical Chemistry)
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Abstract

Due to recent advances in disease proteomics, many disease-related proteins have been found. It is expected that there will be therapeutically useful proteins among them. However, it is clinically difficult to use most proteins as effective and safe drugs because of their very low stability and pleiotropic actions in vivo. To promote disease proteomic based drug development for protein therapies, we have attempted to develop an optimal polymer-conjugation system for improving the therapeutic potency of proteins. In this review, we introduce this innovative protein-drug system.
Keywords: PEGylation; polyvinyl pyrrolidone; Tumor necrosis factor-alpha; Interluekin-6. PEGylation; polyvinyl pyrrolidone; Tumor necrosis factor-alpha; Interluekin-6.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Shibata, H.; Nakagawa, S.; Tsutsumi, Y. Optimization of Protein Therapies by Polymer-Conjugation as an Effective DDS. Molecules 2005, 10, 162-180.

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