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Inquiries into the Nature of Free Energy and Entropy in Respect to Biochemical Thermodynamics
Department of Surgery, Ohio State University, Columbus, Ohio 43210, USA
Received: 2 May 2000; Accepted: 29 July 2000 / Published: 9 August 2000
Abstract: Free energy and entropy are examined in detail from the standpoint of classical thermodynamics. The approach is logically based on the fact that thermodynamic work is mediated by thermal energy through the tendency for nonthermal energy to convert spontaneously into thermal energy and for thermal energy to distribute spontaneously and uniformly within the accessible space. The fact that free energy is a Second-Law, expendable energy that makes it possible for thermodynamic work to be done at finite rates is emphasized. Entropy, as originally defined, is pointed out to be the capacity factor for thermal energy that is hidden with respect to temperature; it serves to evaluate the practical quality of thermal energy and to account for changes in the amounts of latent thermal energies in systems maintained at constant temperature. With entropy thus operationally defined, it is possible to see that TDS° of the Gibbs standard free energy relation DG°= DH°-TDS° serves to account for differences or changes in nonthermal energies that do not contribute to DG° and that, since DH° serves to account for differences or changes in total energy, complete enthalpy-entropy (DH° - TDS°) compensation must invariably occur in isothermal processes for which TDS° is finite. A major objective was to clarify the means by which free energy is transferred and conserved in sequences of biological reactions coupled by freely diffusible intermediates. In achieving this objective it was found necessary to distinguish between a 'characteristic free energy' possessed by all First-Law energies in amounts equivalent to the amounts of the energies themselves and a 'free energy of concentration' that is intrinsically mechanical and relatively elusive in that it can appear to be free of First-Law energy. The findings in this regard serve to clarify the fact that the transfer of chemical potential energy from one repository to another along sequences of biological reactions of the above sort occurs through transfer of the First-Law energy as thermal energy and transfer of the Second-Law energy as free energy of concentration.
Keywords: Temperature; Latent thermal energy; Chemical potential energy; Enthalpy-entropy compensation; Hydrophobic effect; van't Hoff enthalpy; Free energy transfer and conservation
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Stoner, C.D. Inquiries into the Nature of Free Energy and Entropy in Respect to Biochemical Thermodynamics. Entropy 2000, 2, 106-141.
Stoner CD. Inquiries into the Nature of Free Energy and Entropy in Respect to Biochemical Thermodynamics. Entropy. 2000; 2(3):106-141.
Stoner, Clinton D. 2000. "Inquiries into the Nature of Free Energy and Entropy in Respect to Biochemical Thermodynamics." Entropy 2, no. 3: 106-141.