Next Article in Journal
Statistical Information: A Bayesian Perspective
Next Article in Special Issue
Is Cholesterol Sulfate Deficiency a Common Factor in Preeclampsia, Autism, and Pernicious Anemia?
Previous Article in Journal
Shannon’s Sampling Theorem for Bandlimited Signals and Their Hilbert Transform, Boas-Type Formulae for Higher Order Derivatives—The Aliasing Error Involved by Their Extensions from Bandlimited to Non-Bandlimited Signals
Previous Article in Special Issue
The Completed Self: An Immunological View of the Human-Microbiome Superorganism and Risk of Chronic Diseases
Entropy 2012, 14(11), 2227-2253; doi:10.3390/e14112227

Empirical Data Confirm Autism Symptoms Related to Aluminum and Acetaminophen Exposure

1,* , 2
1 Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA 2 Internal Medicine Group Practice, PhyNet, Inc., Longview, TX 75604, USA
Expression of Concern Note added on 17 September 2015 by the Editors: The editors of the journal have been alerted to concerns over potential bias in opinions and bias in the choice of citation sources used in this article. We note that the authors stand by the content as published. Since the nature of the claims against the paper concern speculation and opinion, and not fraud or academic misconduct, the editors would like to make readers aware that the approach to collating literature citations for this article was likely not systematic and may not reflect the spectrum of opinions on the issues covered by the article. Please refer to our policy regarding possibly controversial articles.
* Author to whom correspondence should be addressed.
Received: 24 September 2012 / Revised: 16 October 2012 / Accepted: 5 November 2012 / Published: 7 November 2012
(This article belongs to the Special Issue Biosemiotic Entropy: Disorder, Disease, and Mortality)
Download PDF [441 KB, 24 February 2015; original version 24 February 2015]


Autism is a condition characterized by impaired cognitive and social skills, associated with compromised immune function. The incidence is alarmingly on the rise, and environmental factors are increasingly suspected to play a role. This paper investigates word frequency patterns in the U.S. CDC Vaccine Adverse Events Reporting System (VAERS) database. Our results provide strong evidence supporting a link between autism and the aluminum in vaccines. A literature review showing toxicity of aluminum in human physiology offers further support. Mentions of autism in VAERS increased steadily at the end of the last century, during a period when mercury was being phased out, while aluminum adjuvant burden was being increased. Using standard log-likelihood ratio techniques, we identify several signs and symptoms that are significantly more prevalent in vaccine reports after 2000, including cellulitis, seizure, depression, fatigue, pain and death, which are also significantly associated with aluminum-containing vaccines. We propose that children with the autism diagnosis are especially vulnerable to toxic metals such as aluminum and mercury due to insufficient serum sulfate and glutathione. A strong correlation between autism and the MMR (Measles, Mumps, Rubella) vaccine is also observed, which may be partially explained via an increased sensitivity to acetaminophen administered to control fever.
Keywords: autism; vaccines; MMR; HEP-B; glutathione; sulfate; cholesterol sulfate; aluminum; mercury; acetaminophen autism; vaccines; MMR; HEP-B; glutathione; sulfate; cholesterol sulfate; aluminum; mercury; acetaminophen
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
MDPI and ACS Style

Seneff, S.; Davidson, R.M.; Liu, J. Empirical Data Confirm Autism Symptoms Related to Aluminum and Acetaminophen Exposure. Entropy 2012, 14, 2227-2253.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


Cited By

[Return to top]
Entropy EISSN 1099-4300 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert