Special Issue "Biosemiotic Entropy: Disorder, Disease, and Mortality"
A special issue of Entropy (ISSN 1099-4300).
Deadline for manuscript submissions: closed (31 October 2012)
Prof. Dr. John W. Oller, Jr.
Department of Communicative Disorders, University of Louisiana at Lafayette, P. O. Box 43170, Lafayette, LA 70504-3170, USA
Interests: biosemiotics; etiology of communication disorders; measurement of human abilities and severity of disabilities; intelligence theory; pragmatic information; pragmatic mapping theory; systems grammar
The simplest and most informative linguistic messages are the kind found in ordinary true narratives. Such valid messages ― laden with pragmatic information ― provide the limiting antithesis of biosemiotic entropy. Generalizing from linguistic to biological systems, and taking account of some of the countless ways any complex arrangement of symbols can be rendered senseless, the thesis to be explored in this special issue is that the corruption of biological messages from genetics upward to epigenetics, proteins, cells, tissues, and the organs of viable organisms ― which can be described as biosemiotic entropy ― is, unsurprisingly, the proximate cause of disorders, diseases, and mortality. We invite contributions ― pro, con, or offering any plausible alternative ― to the idea that corrupted biological messages account for (but, of course, are not limited to) anaphylaxis, preeclampsia, sudden death syndrome, immune disorders, autism, and so forth. Empirical and theoretical articles are invited exploring pathways by which toxins, disease agents, and their interactions, and/or injuries from microwave, electromagnetic, radiological, or other energy sources can be shown to increase biosemiotic entropy. Empirically grounded arguments showing how cascading series of effects lead to certain injuries, diseases, and/or known disorders are preferred.
Prof. Dr. John W. Oller, Jr.
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Entropy is an international peer-reviewed Open Access monthly journal published by MDPI.
- abstraction theory
- biosemiotic entropy
- immune disorders
- mortality theory
- pragmatic mapping
- pragmatic information
- theoretical linguistics
- theory of true narratives
Entropy 2012, 14(8), 1399-1442; doi:10.3390/e14081399
Received: 29 June 2012; in revised form: 19 July 2012 / Accepted: 20 July 2012 / Published: 2 August 2012| Download PDF Full-text (1223 KB)
Entropy 2012, 14(10), 1953-1977; doi:10.3390/e14101953
Received: 28 September 2012; in revised form: 16 October 2012 / Accepted: 16 October 2012 / Published: 18 October 2012| Download PDF Full-text (415 KB)
Review: The Completed Self: An Immunological View of the Human-Microbiome Superorganism and Risk of Chronic Diseases
Entropy 2012, 14(11), 2036-2065; doi:10.3390/e14112036
Received: 13 September 2012; in revised form: 18 October 2012 / Accepted: 19 October 2012 / Published: 25 October 2012| Download PDF Full-text (467 KB)
Entropy 2012, 14(11), 2227-2253; doi:10.3390/e14112227
Received: 24 September 2012; in revised form: 16 October 2012 / Accepted: 5 November 2012 / Published: 7 November 2012| Download PDF Full-text (441 KB)
Review: Is Cholesterol Sulfate Deficiency a Common Factor in Preeclampsia, Autism, and Pernicious Anemia?
Entropy 2012, 14(11), 2265-2290; doi:10.3390/e14112265
Received: 12 September 2012; in revised form: 21 October 2012 / Accepted: 6 November 2012 / Published: 8 November 2012| Download PDF Full-text (447 KB)
Review: Is Endothelial Nitric Oxide Synthase a Moonlighting Protein Whose Day Job is Cholesterol Sulfate Synthesis? Implications for Cholesterol Transport, Diabetes and Cardiovascular Disease
Entropy 2012, 14(12), 2492-2530; doi:10.3390/e14122492
Received: 8 October 2012; in revised form: 28 November 2012 / Accepted: 4 December 2012 / Published: 7 December 2012| Download PDF Full-text (618 KB)
Concept Paper: Biosemiotic Entropy of the Genome: Mutations and Epigenetic Imbalances Resulting in Cancer
Entropy 2013, 15(1), 234-261; doi:10.3390/e15010234
Received: 1 November 2012; in revised form: 30 December 2012 / Accepted: 11 January 2013 / Published: 16 January 2013| Download PDF Full-text (6400 KB)
Entropy 2013, 15(1), 372-406; doi:10.3390/e15010372
Received: 8 October 2012; in revised form: 14 January 2013 / Accepted: 15 January 2013 / Published: 22 January 2013| Download PDF Full-text (777 KB)
Review: Glyphosate’s Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome: Pathways to Modern Diseases
Entropy 2013, 15(4), 1416-1463; doi:10.3390/e15041416
Received: 15 January 2013; in revised form: 10 April 2013 / Accepted: 10 April 2013 / Published: 18 April 2013| Download PDF Full-text (518 KB) |
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Type of Paper: Article
Title: Is Cholesterol Sulfate Deficiency a Major Factor in Preeclampsia and in Autism-related Increased Risk to Adverse Reactions to Vaccines?
Authors: Stephanie Seneff 1, Robert Davidson 2 and Jingjing Liu 1
Affiliations: 1 Computer Science and Artificial Intelligence Laboratory, MIT, 32 Vassar Street, Cambridge, MA 01890, USA; E-Mails: Seneff@csail.mit.edu (S.S.); email@example.com (J.L.)
2 Internal Medicine Group Practice, PhyNet, Inc. Longview, TX 75605, USA; E-Mail: firstname.lastname@example.org (R.D.)
Abstract: In a recent paper, we proposed that a contributing factor in autism is a deficiency in cholesterol sulfate supply. In this paper, we investigate a link between preeclampsia and subsequent autism in the child, and we hypothesize that both conditions can be attributed to a severe depletion of cholesterol sulfate. Through studies on the VAERS (Vaccine Adverse Event Reporting System) database, we demonstrate a strong statistical relationship among the symptoms associated with autism and the symptoms associated with preeclampsia, pernicious anemia, and serious adverse reactions to vaccines. We show that VAERS reports associated with symptoms typical of pernicious anemia produce both a set of symptoms that are highly correlated with preeclampsia and another set highly correlated with autism. We explain this observation via an argument that, in a severe reaction, the cascade of events subsequent to vaccination reflects a profuse production of nitric oxide (NO) and consequential destruction of both red blood cells (RBCs) and cobalamin. This may explain the diverse symptoms associated with both preeclampsia and severe vaccine adverse reactions. We argue that excess NO synthesis, induced by the aluminum and antigen in vaccines, results in hemolysis of RBCs, which allows hemoglobin to scavenge the excess NO, converting it to nitrate. The NO is also scavenged by cobalamin, leading to its inactivation and subsequent pernicious anemia. Finally, we demonstrate that severe adverse reactions to vaccines can be associated with life-threatening conditions related to the heart and brain, as well as stillbirth, when the vaccine is administered to a woman in the third-trimester of pregnancy, as demonstrated by statistical analysis of the Gardasil records.
Keywords: autism; preeclampsia; nitric oxide; cobalamin; cholesterol sulfate; red blood cells; vaccines
Type of Paper: Review
Title: Multiple Layers of Patterns Affect the Risk of Chronic Diseases
Author: Rodney R. Dietert
Affiliation: Department of Microbiology and Immunology, Cornell University, Ithaca, NY USA; E-Mail: email@example.com
Abstract: Chronic diseases are the greatest killer worldwide. They cause not only a majority of mortality but also disability, reduced quality of life and the overburdening of our healthcare systems. When viewed across a lifetime, these diseases and conditions exist as an interconnected web of comorbid health risks. These disease patterns frequently emerge during childhood beginning with a root entryway condition (e.g., childhood asthma or type 1 diabetes) then progress to include additional chronic diseases with aging. Misregulated inflammation is a pivotal cellular-molecular signal for these interlinked patterns of disease. Beyond the biosemiotic patterns that link these diseases to each other, there are additional layers of patterns that feed into the chronic disease web. These include: patterns of direct environmental insult (e.g., toxic chemicals, drugs, radiation, diet,), physical-psychological trauma patterns, cognitive-perception patterns, and transgenerational epigenetic patterns. This review will discuss how these additional patterns over-lay the interconnected web of chronic diseases and affect the likelihood of disorder (inflammatory-immune dysfunction), disability and/or premature death. Consideration of these multiple- layered patterns may provide a useful strategy for both individual- and population-based risk reduction of chronic diseases.
Last update: 5 October 2012