Keywordsaneuploidy evolution; canine; sarcomas; DNA index; soft tissue sarcoma; hypoxia; hypoxia-inducible factor; HIFs; osteosarcoma; metastasis; expression profiling; network analysis; Dynemo; protein kinase C epsilon; sarcomas; angiogenesis; endothelial cells; tumor microenvironment; sarcoma; mTOR inhibitors; irinotecan; temsirolimus; phase I; MPNST; neurofibromatosis; nerve sheath tumor; atypical neurofibroma; low grade MPNST; liposarcoma; chemotherapy; molecular-based therapy; clinical trials; head and neck sarcomas; soft tissue sarcomas; osteogenic sarcomas; sarcoma; pediatrics; protons; ewings; osteosarcoma; rhabdomyosarcoma; chordoma; chondrosarcoma