Pathophysiology of Spinal Cord Injury (SCI)

Edited by
December 2022
258 pages
  • ISBN978-3-0365-5888-2 (Hardback)
  • ISBN978-3-0365-5887-5 (PDF)

This book is a reprint of the Special Issue Pathophysiology of Spinal Cord Injury (SCI) that was published in

Biology & Life Sciences

Spinal cord injury (SCI) leads to paralysis, sensory, and autonomic nervous system dysfunctions. However, the pathophysiology of SCI is complex, and not limited to the nervous system. Indeed, several other organs and tissue are also affected by the injury, directly or not, acutely or chronically, which induces numerous health complications. Although a lot of research has been performed to repair motor and sensory functions, SCI-induced health issues are less studied, although they represent a major concern among patients. There is a gap of knowledge in pre-clinical models studying these SCI-induced health complications that limits translational applications in humans. This reprint describes several aspects of the pathophysiology of spinal cord injuries. This includes, but is not limited to, the impact of SCI on cardiovascular and respiratory functions, bladder and bowel function, autonomic dysreflexia, liver pathology, metabolic syndrome, bones and muscles loss, and cognitive functions.

  • Hardback
© 2022 by the authors; CC BY-NC-ND license
micturition; external urethral sphincter; spinal cord injury; serotonin; electromyogram; spinal cord injury; fecal microbiota transplant; inflammation; anxiety; rehabilitation; autonomic dysreflexia; spinal cord injury; immune dysfunction; SCI-IDS; primary afferents; nociceptor; reach-to-grasp; forelimb function; upper extremity function; cardiovascular; contusion; neuroplasticity; spinal cord injury; osteopenia; bone loss; recovery of function; spinal cord injury; monoamines; serotonin; GABA; neuromodulation; pain; autonomic dysreflexia; spasticity; ionic plasticity; spinal cord injury; repetitive transcranial magnetic stimulation; phrenic motor network; neuroplasticity; motoneuron excitability; diaphragm muscle; spinal cord injury severity; cardiometabolic disease; liver and cardiac dysfunctions; fibrosis; spinal cord injury; pathophysiology; inflammation; oxidative stress; spinal cord injury; contusion model; respiratory function; diaphragmatic activity; phrenic motoneurons; neuroinflammation; cytokines; tumor necrosis factor; immune cells; microglia