Keywordsn/a; genome evolution; origin of proteins; ribosome evolution; origin of the genetic code; aminoacyl-tRNA synthetase; homocysteine editing; thioester; coenzyme A; non-coded peptide synthesis; prebiotic chemistry; thioester world; evolution; RNY code; Standard genetic code; evolution of the genetic code; frozen code; degeneracy; aminoacyl-tRNA synthetases; symmetry; tRNA; aaRS; genetic code; evolution; lateral gene transfer; synthetic life; non-canonical amino acid; rewritten genetic code; restrictive post-transcriptional modification; anticodon identity element; frozen accident; genetic code; genetic engineering; evolution; synthetic biology; binding; triplet; codon; anticodon; DRT; translation; evolution; speciation; protein folds; tRNA; ribosome; genetic code; (proto)tRNA Dimer-Directed Protein Synthesis; self-reference; modularity; error-compensation; metabolism chronology; protein stability; punctuation; genetic code evolution; frozen accident; stereochemical theory; coevolution theory; error minimization; RNA world; proto-tRNAs; tRNA identity; tRNA recognition; operational code; bayesian networks; information theory; distribution divergence